琥珀酸在内分泌、间充质和上皮肿瘤中的肿瘤代谢物作用

IF 0.4 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Iranian Red Crescent Medical Journal Pub Date : 2022-11-19 DOI:10.32592/ircmj.2022.24.12.2395

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引用次数: 0

摘要

琥珀酸脱氢酶（SDH）是真核生物线粒体的一种多方面酶，负责将琥珀酸转化为富马酸盐，作为克雷布斯循环的一种成分。它的功能障碍发生在几种与内分泌和上皮肿瘤相关的恶性肿瘤中。SDH是一种由一些亚基组成的酶复合物。琥珀酸被认为是一种肿瘤代谢产物；因此，SDH突变的发现可以将琥珀酸盐的变化与肿瘤的发生直接联系起来。实验室技术的进步使得能够对几种类型的癌症中的琥珀酸积累进行分析和鉴定。在本研究中，我们综述了SDH突变和琥珀酸盐的改变在肿瘤发生中的潜在作用，以及作为早期检测恶性肿瘤的肿瘤标志物。

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Succinate as an Oncometabolite in Endocrine, Mesenchymal, and Epithelial Tumors

Succinate dehydrogenase (SDH) is a multifaceted enzyme for the mitochondria of eukaryotes, which is responsible for converting succinate to fumarate as a component in the Krebs cycle. Its dysfunction occurs in several malignancies associated with endocrine and epithelial tumors. SDH is an enzymatic complex made of some subunits. Succinate is recognized as an oncometabolite; therefore, the discovery of SDH mutations can give a straight connection between the changes of succinate and tumorigenesis. Progresses in laboratory technologies made it possible to make profiles of and identify succinate accumulation in several types of cancer. In this study, we reviewed the potential roles of SDH mutation and alteration of succinate in tumorigenesis and as tumor markers for the early detection of malignancies.

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来源期刊

Iranian Red Crescent Medical Journal MEDICINE, GENERAL & INTERNAL-

CiteScore

1.16

自引率

0.00%

发文量

期刊介绍： The IRANIAN RED CRESCENT MEDICAL JOURNAL is an international, English language, peer-reviewed journal dealing with general Medicine and Surgery, Disaster Medicine and Health Policy. It is an official Journal of the Iranian Hospital Dubai and is published monthly. The Iranian Red Crescent Medical Journal aims at publishing the high quality materials, both clinical and scientific, on all aspects of Medicine and Surgery