ph响应型玉米蛋白-锌npc - pda /HA纳米颗粒的制备与表征

IF 0.4 4区医学 Q4 PHARMACOLOGY & PHARMACY

Acta poloniae pharmaceutica Pub Date : 2023-05-04 DOI:10.32383/appdr/163050

Huixiang Lu, Ming Yang, Xueying Tian, Xianhui He, Yujun Lu, Qian-rong Peng

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引用次数: 0

摘要

光动力疗法（PDT）已成为一种非侵入性治疗方式，光敏剂（PS）在治疗肿瘤中发挥着不可或缺的作用。本研究提出了一种新型的Zein纳米粒子（ZP），该纳米粒子包封酞菁锌（ZnPc），通过静脉递送靶向肿瘤。ZPs是通过相分离工艺制备的。ZPs的改性是通过包封聚多巴胺（PDA）和透明质酸（HA）来实现的，以保持光热、pH响应性和肿瘤靶向性。研究了光热和光动力效应的理化性质、体外释放和体外评价。以人癌症细胞株A549为模型，通过细胞毒性试验分析其生物安全性。优良的生物安全性和显著的抗肿瘤效果表明，新型ZPs可作为癌症替代治疗的潜在候选药物。

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Preparation and characterization of pH-responsive Zein-ZnPc-PDA/HA nanoparticles intended for tumor therapy

Photodynamic therapy (PDT) has emerged as a non-invasive modality where photosensitizer (PS) plays an indispensable role for treating tumors. This study proposes a novel Zein nanoparticle (ZP) encapsulating Zinc phthalocyanine (ZnPc) that targets tumor through intravenous delivery. The ZPs were prepared by phase separation process. Modification of ZPs were realized through encapsulation of polydopamine (PDA) and hyaluronic acid (HA) in order to maintain photothermal, pH-responsive, and tumor-targeting properties. The physiochemical properties, in vitro release, and in vitro evaluation of photothermal and photodynamic effects were studied. The biosafety was analyzed through cytotoxicity assay using human lung cancer cell line A549 as model. The excellent biosafety and significant anti-tumor effect demonstrated that the novel ZPs can be potential candidates for the alternative treatment of cancer.

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来源期刊

Acta poloniae pharmaceutica 医学-药学

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.