鼻咽部透明细胞癌1例报告及文献复习

IF 2.3 Q1 OTORHINOLARYNGOLOGY
Madison J Malfitano, M. Norris, Wesley H. Stepp, G. Santarelli, T. Samulski, B. Senior, C. Ebert, B. Thorp, A. Zanation, A. Kimple
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引用次数: 5

摘要

背景透明质透明细胞癌(HCCCs)是一种罕见的、低度恶性肿瘤,最常见于小唾液腺,主要发生在腭和舌头,但也可发生在任何小唾液腺部位,包括鼻咽。方法报告1例原发性鼻咽HCCC。由于这种肿瘤的罕见性和位置,我们进行了文献检索,以确定最常见的症状、治疗策略和结果。结果一名48岁的男性接受了4.5 右侧鼻咽cm肿块,病理学提示为中度黏液表皮样癌。在与患者讨论处理后,进行了内镜下切除术。最终病理学显示HCCC,在荧光原位杂交(FISH)研究中Mastermind样2(MAML2)阴性和Ewing肉瘤断点区1(ESWR1)阳性基因重排后证实。对其他鼻咽HCCC病例的文献回顾显示,通过手术和放射治疗,其表现多种多样,总体预后良好。结论HCCCs是一种罕见的、低度恶性的小唾液腺肿瘤,可表现为鼻咽肿块,症状多种多样,但经常涉及耳鼻功能紊乱。HCCC是一种惰性肿瘤,当通过手术切除和辅助放疗进行适当治疗时,预后良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nasopharyngeal Hyalinizing Clear Cell Carcinoma: A Case Report and Review of the Literature
Background Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors which most often arise from the minor salivary glands primarily in palate and tongue but can arise in any location with minor salivary glands including the nasopharynx. Methods A case report of primary nasopharyngeal HCCC is presented. Because of the rarity of this tumor and location, a literature search was conducted to determine the most common presenting symptoms, treatment strategies, and outcomes. Results A 48-year-old man underwent biopsy of a 4.5 cm mass of the right nasopharynx with pathology suggesting an intermediate grade mucoepidermoid carcinoma. After discussing management with the patient, an endoscopic resection was performed. Final pathology revealed an HCCC which was confirmed after negative Mastermind-like 2 (MAML2) and positive Ewing sarcoma breakpoint region 1 (ESWR1) gene rearrangements on fluorescence in situ hybridization (FISH) studies. Literature review of other nasopharyngeal HCCC cases shows diverse presentation and overall excellent prognosis through surgical and radiation therapy. Conclusion HCCCs are rare, low-grade malignant tumors of the minor salivary glands and can present as a nasopharyngeal mass. Presenting symptoms are diverse but frequently involve otologic and sinonasal disturbances. HCCC is an indolent tumor with an excellent prognostic outcome when treated appropriately with surgical resection and adjuvant radiotherapy.
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来源期刊
Allergy & Rhinology
Allergy & Rhinology OTORHINOLARYNGOLOGY-
CiteScore
3.30
自引率
4.50%
发文量
11
审稿时长
15 weeks
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