Recanalization of the middle cerebral artery after prolonged induced hypertensive therapy to rescue early neurologic deterioration

Early neurologic deterioration (END) is a common complication occurring in up to one-third of patients with acute ischemic stroke [1]. Proximal arterial occlusion is a risk factor for predicting END [2]. Pharmacologically induced hypertensive therapy (PIHT) is a therapeutic option for END, which acts by increasing collateral flow, thereby preventing the expansion of the infarct core [3,4]. Phenylephrine is mainly used for PIHT because it selectively binds to alpha-1 receptors and causes peripheral vasoconstriction Recanalization of the middle cerebral artery after prolonged induced hypertensive therapy to rescue early neurologic deterioration Han Kyu Na, MD; Taewon Kim, MD; Jung Yon Yum, MD; Woohyun Park, MD; Joonho Kim, MD; Seokhyun Kim, MD; Jong Hun Kim, MD; Kwon-Duk Seo, MD Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang, Korea 2 Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea CASE REPORT