月桂水提取物对内毒素诱导的家兔氧化应激的保护作用

IF 1.2 Q4 PHARMACOLOGY & PHARMACY
M. Salawu, Muhammed Iduze, A. Ayuba, H. Oloyede
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引用次数: 1

摘要

摘要研究了月桂口服联合给药对大肠杆菌内毒素暴露家兔的保护作用。二十五(25)只兔子被随机分为五组,每组五只兔子——A组,500内毒素单位(EU)kg−1 bw,B组,500 EU kg−1 bw+6.6 mg kg−1 bw提取物,C组,500 EUkg−1 BV+3.3 mg kg−一bw提取物,D组,500欧盟kg−1 GW+抗坏血酸(100 mg kg−1bw)和E组(0 EU kg−1BW)。在前7天给兔子预先给予月桂叶提取物,然后开始内毒素口服给药,每天重复给药21天。在第7天和第21天结束时,进行血清超氧化物歧化酶、谷胱甘肽S-转移酶、还原型谷胱甘肽、过氧化氢酶和丙二醛的测定。处死动物以收集肾脏和肝脏。肝脏和肾脏的组织病理学分析显示,与阴性对照相比,暴露于500 EU kg−1 bw内毒素的21 d+月桂叶提取物,剂量分别为6.6和3.3 mg kg−1 bw,可增加超氧化物歧化酶、谷胱甘肽S-转移酶、还原型谷胱甘肽和过氧化氢酶的比活性。在用月桂叶水提取物处理的组中丙二醛浓度降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective Effects of Aqueous Extract of Bay Leaf (Laurus Nobilis) on Endotoxin-Induced Oxidative Stress in Rabbits
ABSTRACT The protective effect of oral co-administration of Laurus nobilis on Escherichia coli endotoxin-exposed rabbits was studied. Twenty-five (25) rabbits were randomized into five groups containing five rabbits each – Group A, 500 Endotoxin Unit (EU) kg−1 bw, Group B, 500 EU kg−1 bw + 6.6 mg kg−1 bw extract, Group C, 500 EU kg−1 bw + 3.3 mg kg−1 bw extract, Group D, 500 EU kg−1 bw + Ascorbic acid (100 mg kg−1 bw) and Group E (0 EU kg−1 bw). The rabbits were pre-administered with the bay leaf extract in the first 7 days, then endotoxin oral administration was started and repeated daily for 21 d. At the end of days 7 and 21, assays for the serum superoxide dismutase, glutathione S-transferase, reduced glutathione, catalase, and malondialdehyde were done. The animals were sacrificed to collect kidneys and liver. Histopathological analysis of the liver and kidneys showed that exposure to 500 EU kg−1 bw endotoxin for 21 d + bay leaf extract at 6.6 and 3.3 mg kg−1 bw increased specific activities of superoxide dismutase, glutathione S-transferase, and reduced glutathione and catalase compared to the negative control. There was a decrease in the concentration of malondialdehyde in groups treated with the aqueous extract of bay leaf.
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来源期刊
Journal of Herbs, Spices and Medicinal Plants
Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine
CiteScore
3.00
自引率
0.00%
发文量
36
期刊介绍: The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.
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