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GaAlAs激光预处理可增强ADSCs在大鼠皮肤光老化中的作用

中华医学美学美容杂志 Pub Date : 2019-02-15 DOI:10.3760/CMA.J.ISSN.1671-0290.2019.01.003

Xuan Liao, Chen Zheng, Jun-Xian Liang, Su Huang, Sheng-Hong Li, Li-Ling Xiao

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引用次数: 0

摘要

目的探讨脂肪源性干细胞(ADSCs)对GaAlAs激光预处理后光老化皮肤的影响。方法从健康wistar大鼠体内分离ADSCs，建立脂肪源性干细胞培养体系。采用波长为650 nm 4 J/cm2的GaAlAs激光对ADSCs进行预处理。建立大鼠光老化衰老模型。采用不同剂量的ADSCs和低能量激光ADSCs预处理光老化皮肤，观察低能量激光预处理前后表皮和真皮层的形态学变化。结果当ADSCs浓度为103/100 μl时，ADSCs处理组与GaAlAs预处理组的表皮厚度和真皮厚度差异无统计学意义(P < 0.05)。在104/100 μl浓度下，GaAlAs预处理组表皮厚度显著低于ADSCs组(P<0.05)。当ADSCs浓度为5×104/100 μl时，GaAlAs预处理组表皮厚度显著降低，真皮厚度显著增加，与ADSCs组差异有统计学意义(P<0.05)。结论GaAlAs激光预处理可增强ADSCs抗皮肤光老化能力。关键词:激光器;多能干细胞;细胞衰老;GaAlAs;脂肪来源的干细胞

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GaAlAs laser pretreatment enhances the function of ADSCs in photoaging of the skin in rats

Objective To investigate the effect of adipose-derived stem cells (ADSCs) on photoaging skin after laser pretreatment with GaAlAs. Methods ADSCs were isolated from healthy wistar rats, ADSCs were isolated and cultured to establish an adipose-derived stem cell culture system. ADSCs were pretreated with GaAlAs laser at a wavelength of 650 nm 4 J/cm2. A rat model of photoaging aging was established. Different doses of ADSCs and low energy laser ADSCs were pretreated with ADSCs for the treatment of photoaging skin, and the morphological changes of epidermis and dermis were observed before and after treatment with low energy laser pretreatment. Results When the concentration of ADSCs was 103/100 μl, there was no significant difference in epidermal thickness and dermal thickness between ADSCs treated group and GaAlAs pretreatment group (P>0.05). The thickness of epidermis in the GaAlAs pretreatment group was significantly lower than that in the ADSCs group (P<0.05) at 104/100 μl. When the concentration of ADSCs was 5×104/100 μl, the epidermal thickness of the GaAlAs pretreatment group decreased significantly and the thickness of the dermis increased significantly, which was significantly different from that of the ADSCs group (P<0.05). Conclusions GaAlAs laser pretreatment can enhance ADSCs anti-skin photoaging ability. Key words: Lasers; Multipotent stem cells; Cellular senescence; GaAlAs; Adipose-derived stem cells

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来源期刊

中华医学美学美容杂志

中华医学美学美容杂志

自引率

0.00%

发文量

4641

期刊介绍： "Chinese Journal of Medical Aesthetics and Cosmetology" is a high-end academic journal focusing on the basic theoretical research and clinical application of medical aesthetics and cosmetology. In March 2002, it was included in the statistical source journals of Chinese scientific and technological papers of the Ministry of Science and Technology, and has been included in the full-text retrieval system of "China Journal Network", "Chinese Academic Journals (CD-ROM Edition)" and "China Academic Journals Comprehensive Evaluation Database". Publishes research and applications in cosmetic surgery, cosmetic dermatology, cosmetic dentistry, cosmetic internal medicine, physical cosmetology, drug cosmetology, traditional Chinese medicine cosmetology and beauty care. Columns include: clinical treatises, experimental research, medical aesthetics, experience summaries, case reports, technological innovations, reviews, lectures, etc.

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