亚临界水中过氧化氢对氢氯噻嗪的矿化作用

Q3 Chemistry
Erdal Yabalak, Özkan Görmez, Yahya Nural
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引用次数: 2

摘要

本文以H2 O2为氧化剂,以亚临界水为介质,研究了用于治疗高血压的利尿药物氢氯噻嗪的矿化作用。采用响应面法对温度、处理时间和氧化剂浓度等实验参数进行了优化。在403K、80mM过氧化氢和147.3min下获得了85.22%的TOC去除率。通过方差分析评估了所执行方法的可靠性,并提出了氢氯噻嗪去除TOC的理论方程。模型的F值和p值分别为62.88和低于0.0001。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mineralization of Hydrochlorothiazide using Hydrogen Peroxide in Subcritical Water
In this paper, we investigated the mineralization of hydrochlorothiazide, a diuretic drug which is used for the treatment of hypertension, using H 2 O 2 as the oxidizing agent in subcritical water as a medium. Response surface methodology was applied to optimize experimental parameters such as temperature, treatment time, and concentration of the oxidizing agent. 85.22% of TOC removal was obtained at 403 K, 80 mM of hydrogen peroxide and 147.3 min. The reliability of the performed method was evaluated by ANOVA and the theoretical equation of TOC removal of hydrochlorothiazide was proposed. F and p values of the model were determined as 62.88 and lower than 0.0001, respectively.
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
81
审稿时长
5 weeks
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