癌症患者血清miRNA-126和miRNA-30c的表达及其临床意义

Q4 Medicine

肿瘤研究与临床 Pub Date : 2019-12-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2019.12.004

Hongjian Dou, Junling Han, Y. Xing

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引用次数: 0

摘要

目的探讨血清miRNA-126（miR-126）和miRNA-30c（miR-30c）在癌症患者中的表达，分析其与癌症发生的关系及其诊断价值。方法选择2014年1月至2018年12月在解放军联勤保障部队第928医院确诊的110例胰腺癌癌症患者和110名健康人作为对照组。采用实时定量聚合酶链反应（qRT-PCR）方法检测110例患者和健康对照者血清中miR-126和miR-30c的表达水平，并分析其与癌症临床病理特征的关系。结果胰腺癌癌症组血清miR-126和miR-30c水平均低于健康对照组（0.43±0.12 vs.1.02±0.27，t=19.394，P＜0.05），但与肿瘤大小、分化程度、TNM分期、淋巴结转移等因素有关（均＜0.05），而吸烟、饮酒和胆结石是胰腺癌的危险因素（均P＜0.05），血清miR-126和miR-30c联合检测诊断胰腺癌的曲线下面积为0.906，敏感性为90.80%，特异性为82.20%。二者均可能参与胰腺癌癌症的发生和发展，可作为癌症的早期诊断标志物。关键词：胰腺肿瘤；miRNA-126；miRNA-30c；诊断

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Expressions of serum miRNA-126 and miRNA-30c in patients with pancreatic cancer and their clinical significances

Objective To investigate the expressions of serum miRNA-126 (miR-126) and miRNA-30c (miR-30c) in patients with pancreatic cancer, and to analyze the relationship with the occurrence of pancreatic cancer as well as the diagnostic value. Methods A total of 110 patients with pancreatic cancer diagnosed at the 928th Hospital of the Joint Service Support Force of PLA from January 2014 to December 2018 were selected, and 110 healthy people were also selected as the control group. The expression levels of serum miR-126 and miR-30c of 110 patients and the healthy controls were detected by using real-time quantitative polymerase chain reaction (qRT-PCR), and their relationship with clinicopathological features of pancreatic cancer was analyzed. Results The levels of serum miR-126 and miR-30c in pancreatic cancer group were lower than those in the healthy control group (0.43±0.12 vs. 1.02±0.27, t = 19.394, P 0.05), but related with tumor size, differentiation degree, TNM stage and lymph node metastasis (all P < 0.05). High expression levels of serum miR-126 and miR-30c were protective factors for pancreatic cancer (all P < 0.05), while smoking, drinking and gallstones were risk factors for pancreatic cancer (all P < 0.05). The area under the curve of combined detection of serum miR-126 and miR-30c for diagnosis of pancreatic cancer was 0.906, the sensitivity was 90.80%, and the specificity was 82.20%. Conclusions The expression levels of serum miR-126 and miR-30c in patients with pancreatic cancer are low. Both of them may be involved in the occurrence and development of pancreatic cancer, and may be used as early diagnostic markers of pancreatic cancer. Key words: Pancreatic neoplasms; miRNA-126; miRNA-30c; Diagnosis

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.