Sequential one-pot synthesis of (1→6) amide-linked oligosaccharide mimetics under mild conditions

An efficient and practical synthetic strategy, suitable for one-pot synthesis, for novel amide-linked oligosaccharide mimetics from sugar amino acid precursors is described. Twenty substrates, including twelve amide-linked disaccharide mimetics, four amide-linked trisaccharide mimetics and four amide-linked tetrasaccharide mimetics, were synthesized based on this strategy and its optimal conditions. This potentially general method is featured by high yields, gram-scale synthesis, wide substrate scope, and mild reaction conditions.