DyglomeraⓇ(二花珊瑚提取物)对体脂百分比和体重的影响:一项随机、双盲、安慰剂对照的临床试验

IF 1.3 Q4 FOOD SCIENCE & TECHNOLOGY
J. Youovop, G. Takuissu, Christelle Mbopda, F. Nwang, Raissa Ntentié, Mary-ann A. Mbong, B. Azantsa, Harinder Singh, J. Oben
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引用次数: 0

摘要

简介:先前的研究表明Dyglomera®,一种双青豆(Dichrostachys glomerata)的氢乙醇提取物,对炎症和代谢综合征相关参数有有益作用。然而,它对体脂的影响尚未得到证实。因此,本研究旨在评估Dyglomera®对超重和肥胖受试者的抗肥胖作用。方法:这项为期12周的随机、双盲、安慰剂对照试验以双能x线吸收仪测量体脂百分比、体重和体重指数为疗效终点。另一方面,测量关键生化参数作为次要终点。在T12时,这些参数的值与安慰剂组和Dyglomera®组的T0相比,被用作疗效的衡量标准。结果:Dyglomera®治疗12周后,体重下降6.73 kg (p<0.05),体脂率下降22.85% (p<0.05)。此外,摄入Dyglomera®后,血脂指标、脂肪细胞因子、血糖和转氨酶的血浆活性也有所改善。结论:本研究表明,Dyglomera®在治疗12周后有效降低肥胖受试者的体重,同时伴有体脂和相关疾病的减少。Dyglomera®是一种很好的超重和肥胖管理剂。关键词:肾小球二色粘连,Dyglomera®,体脂率,体重,临床试验
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effects of DyglomeraⓇ (dichrostachys glomerata extract) on body fat percentage and body weight: a randomized, double-blind, placebo-controlled clinical trial
Introduction: Previous studies have shown the beneficial effects of Dyglomera®, a hydroethanolic extract of Dichrostachys glomerata, on inflammation as well as parameters linked to metabolic syndrome. Its effect on body fat was however not verified. The present study was therefore carried out to evaluate the anti-obesity effect of the Dyglomera®, on overweight and obese subjects.Methods: This 12-week randomized, double-blind placebo-controlled trial had percentage body fat measured by dual-energy X-ray absorptiometry, body weight and body mass index set as efficacy endpoints.  On the other hand, key biochemical parameters were measured as secondary endpoints.  The values of these parameters at T12 compared to T0 for the placebo and Dyglomera® groups were used as a measure of the efficacy. Results: Subjects treated with Dyglomera® for 12 weeks showed significant differences, with 6.73 kg (p<0.05) decrease in the body weight and 22.85% (p<0.05) reduction in the percentage body fat. In addition, the markers of lipid profile, adipocytokines, glycemia and transaminases plasmatic activities were also improved by the intake of Dyglomera®.Conclusions: This study shows that Dyglomera® effectively decreases the body weight in obese subjects after 12 weeks of treatment, which was accompanied by a reduction in the body fat and related disorders. Dyglomera®is a good agent for overweight and obesity management.Keywords: Dichrostachys glomerata, Dyglomera®, body fat percentage, body weight, clinical trials.
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来源期刊
Functional Foods in Health and Disease
Functional Foods in Health and Disease FOOD SCIENCE & TECHNOLOGY-
CiteScore
2.20
自引率
20.00%
发文量
47
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