尿路上皮癌的分子生物学

Journal of Cancer Research and Practice Pub Date : 2021-01-01 DOI:10.4103/JCRP.JCRP_1_21

P. Liang, T. Chan, Y. Shiue, Chien-Fen Li

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引用次数: 1

摘要

目的:尿路上皮癌(UC)是世界范围内常见的恶性肿瘤。广泛的基因组数据分析显示UC具有复杂的分子特征。从肿瘤标志的角度综述了参与UC肿瘤发生的分子生物学。数据来源:我们检查了多项UC研究的结果，重点是癌症的特征。结果:UC具有独特的分子通路，涉及持续增殖信号传导、逃避生长抑制因子、抵抗细胞死亡、促进复制不朽、诱导血管生成、激活入侵和转移、基因组不稳定和突变、促肿瘤炎症、能量代谢重编程和逃避免疫破坏。结论:从肿瘤标志的角度，揭示了UC的多方面生物学行为。

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Molecular biology of urothelial carcinoma

Objective: Urothelial carcinoma (UC) is a common malignant tumor worldwide. Extensive genomic data analysis revealed that UC has a complex molecular character. From the perspective of cancer hallmarks reviewed the molecular biology participated in the tumorigenesis of UC. Data Sources: We inspected the results of multiple studies of UC focusing on the hallmarks of cancer. Results: UC has distinctive molecular pathways involved in sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, promotion of replicative immortality, induction of angiogenesis, activation of invasion and metastasis, genome instability and mutation, tumor-promoting inflammation, reprogramming of energy metabolism, and evasion of immune destruction. Conclusion: From the perspective of the hallmark of cancer, we revealed the many-sided biological behavior of UC.

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来源期刊

Journal of Cancer Research and Practice

自引率

0.00%

发文量

审稿时长

24 weeks

期刊介绍： JCRP aims to provide an exchange forum for the cancer researchers and practitioners to publish their timely findings in oncologic disciplines. The scope of the Journal covers basic, translational and clinical research, Cancer Biology, Cancer Immunotherapy, Hemato-oncology, Digestive cancer, Urinary tumor, Germ cell tumor, Breast cancer, Lung cancer, Head and Neck Cancer in a vast range of cancer related topics. The Journal also seeks to enhance and advance the cancer care standards in order to provide cancer patients the best care during the treatments.