{"title":"首先全面了解RTK KIT原生和致癌靶标的有序-无序性质","authors":"Tchertanov Luba, Ledoux Julie","doi":"10.17352/2581-5407.000046","DOIUrl":null,"url":null,"abstract":"Receptors Tyrosine Kinases (RTKs) act as sensors for extracellular ligands, the binding of which triggers dimerization, activation, and autophosphorylation of specific tyrosine (Y) residues in the Cytoplasmic Domain (CD). This leads to the recruitment and activation of multiple downstream signaling proteins, which regulate various aspects of cellular physiology.","PeriodicalId":73166,"journal":{"name":"Global journal of cancer therapy","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets\",\"authors\":\"Tchertanov Luba, Ledoux Julie\",\"doi\":\"10.17352/2581-5407.000046\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Receptors Tyrosine Kinases (RTKs) act as sensors for extracellular ligands, the binding of which triggers dimerization, activation, and autophosphorylation of specific tyrosine (Y) residues in the Cytoplasmic Domain (CD). This leads to the recruitment and activation of multiple downstream signaling proteins, which regulate various aspects of cellular physiology.\",\"PeriodicalId\":73166,\"journal\":{\"name\":\"Global journal of cancer therapy\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Global journal of cancer therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17352/2581-5407.000046\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global journal of cancer therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17352/2581-5407.000046","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets
Receptors Tyrosine Kinases (RTKs) act as sensors for extracellular ligands, the binding of which triggers dimerization, activation, and autophosphorylation of specific tyrosine (Y) residues in the Cytoplasmic Domain (CD). This leads to the recruitment and activation of multiple downstream signaling proteins, which regulate various aspects of cellular physiology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
