mayombensis Leplaea（Pellegrin）Staner的化学成分

IF 1.6 Q3 URBAN STUDIES

TOWN PLANNING REVIEW Pub Date : 2021-06-01 DOI:10.30495/TPR.2021.1922669.1197

Djeukeu Kemmoe Charlie, H. L. Maza, Kenmogne Kouam Ariane, Sewald Norbert, W. J. Duplex, Vardamides Juliette Catherine

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引用次数: 1

摘要

一种新的香豆素信号素，cleomiscosin F（1），以及10种已知化合物，即3，4-ecotirucala-4（28），7，24-trien-21-羟基-21,23-环氧-3-酸（2），3，4-Ecotirucala-4（28）、7，24-trien-3，21-二酸（3），从马良木（Meliaceae）的种子和根中分离得到豆甾醇、β-谷甾醇及其糖苷类化合物，并对它们的光谱数据进行了分析，阐明了它们的结构。一些分离的化合物（3、4和5）在体外对细菌菌株大肠杆菌、枯草芽孢杆菌、琼脂假单胞菌和黄微球菌进行了测试。化合物3对枯草芽孢杆菌、黄微球菌和琼脂假单胞菌表现出良好的活性，MIC值分别为1.7、2.3和9.8µM；而化合物4对黄微球菌显示出显著的活性，MIC值为11.9µM。

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Chemical composition of Leplaea mayombensis (Pellegrin) Staner

One new coumarinolignan, cleomiscosin F (1) along with ten known compounds namely 3,4-secotirucalla-4(28),7,24-trien-21-hydroxy-21,23-epoxy-3-oic acid (2), 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid (3),ceramid A (4),ceramid B (5), mayombensin (6),aridanin (7), stigmasterol and β-sitosterol and their glucosides were isolated from the seeds and roots of Leplaea mayombensis (Meliaceae).Thestructures of the compounds were elucidated based on the interpretation of their spectroscopic data. Some of the isolated compounds (3, 4 and 5) were tested in vitro against bacteria strains Escherichia coli, Bacillus subtilis, Pseudomonas agarici, and Micrococcus luteus. Compound 3 displayed good activity against Bacillus subtilis, Micrococcus luteus, and Pseudomonas agarici with MIC values of 1.7, 2.3 and 9.8µM, respectively; while compound 4 showed significant activity against Micrococcus luteus with MIC value of 11.9µM.

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来源期刊

TOWN PLANNING REVIEW URBAN STUDIES-

CiteScore

3.40

自引率

0.00%

发文量

期刊介绍： Town Planning Review has been one of the world"s leading journals of urban and regional planning since its foundation in 1910. With an extensive international readership, TPR is a well established urban and regional planning journal, providing a principal forum for communication between researchers and students, policy analysts and practitioners. To mark TPR’s centenary in 2010, it is proposed to publish a series of ‘Centenary Papers’ -- review papers that record and reflect on the state of the art in a range of topics in the general field of town and regional planning.