基因-性别相互作用对哮喘发病时间的影响:一项大规模全基因组荟萃分析

IF 2.7 4区医学 Q2 GENETICS & HEREDITY

Genes and Environment Pub Date : 2018-09-15 DOI:10.1183/13993003.CONGRESS-2018.OA2190

Raphael Veil, H. Mohamdi, R. Granell, M. Ege, M. Freidin, M. Imboden, A. James, D. Jarvis, E. Khusnutdinova, C. Laprise, P. Margaritte-Jeannin, Ludmila O. Ogorodova, C. Sarnowski, null Marie-Helene, Dizier A. John Henderson, A. Karunas, E. Mutius, N. Probst-Hensch, B. Leynaert, F. Demenais, E. Bouzigon

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引用次数: 1

摘要

1INSERM U946，遗传变异和人类疾病股;巴黎狄德罗大学、巴黎圣城索邦大学、巴黎化学和生物技术大学研究所(法国)、布里斯托尔大学布里斯托尔医学院、布里斯托尔人口健康科学、布里斯托尔(联合王国)、3路德维希·马克西米利安大学冯·豪纳博士儿童医院;慕尼黑综合肺学中心(CPC-M)，德国慕尼黑肺研究中心(德国)，4托木斯克NRMC托木斯克(俄罗斯联邦)医学遗传学研究所，5瑞士热带和公共卫生研究所;巴塞尔大学(瑞士)，6巴塞尔顿人口医学研究所，肺生理和睡眠医学系，查尔斯·盖尔德纳爵士医院;西澳大利亚大学尼德兰分校(澳大利亚)人口健康学院，帝国理工学院呼吸流行病学，职业医学和公共卫生，国立心肺研究所;MRC-PHE环境与健康中心伦敦(英国)，8俄罗斯科学院乌法联邦研究中心生物化学和遗传学分院;巴什基尔语州立大学遗传学和基础医学系乌法(俄罗斯联邦),9部门des科学fondamentales,魁北克大学Chicoutimi奈(加拿大),10西伯利亚国家医科大学托木斯克(俄罗斯联邦),11 inserm, 700部队,团队的流行病学;巴黎大学(diderot Paris)

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Influence of gene-by-sex interaction on time-to-asthma onset: a large-scale genome-wide meta-analysis

1INSERM U946, Genetic Variation and Human Diseases Unit; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d’Hématologie Paris (France), 2Population Health Sciences, Bristol Medical School, University of Bristol Bristol (United Kingdom), 3Dr von Hauner Children's Hospital, Ludwig Maximilian University; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research Munich (Germany), 4Research Institute of Medical Genetics, Tomsk NRMC Tomsk (Russian Fed.), 5Swiss Tropical and Public Health Institute; University of Basel Basel (Switzerland), 6Busselton Population Medical Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital; School of Population Health, University of Western Australia Nedlands (Australia), 7Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College; MRC-PHE Centre for Environment & Health London (United Kingdom), 8Institute of Biochemistry and Genetics Subdivision of the Ufa Federal Research Center of the Russian Academy of Science; Bashkir State University, Department of Genetics and Fundamental Medicine Ufa (Russian Fed.), 9Département des sciences fondamentales, Université du Québec à Chicoutimi Saguenay (Canada), 10Siberian State Medical University Tomsk (Russian Fed.), 11Inserm, Unit 700, Team of Epidemiology; Université Paris-Diderot Paris 7 Paris (France)

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来源期刊

Genes and Environment Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

27 weeks

期刊介绍： Genes and Environment is an open access, peer-reviewed journal that aims to accelerate communications among global scientists working in the field of genes and environment. The journal publishes articles across a broad range of topics including environmental mutagenesis and carcinogenesis, environmental genomics and epigenetics, molecular epidemiology, genetic toxicology and regulatory sciences. Topics published in the journal include, but are not limited to, mutagenesis and anti-mutagenesis in bacteria; genotoxicity in mammalian somatic cells; genotoxicity in germ cells; replication and repair; DNA damage; metabolic activation and inactivation; water and air pollution; ROS, NO and photoactivation; pharmaceuticals and anticancer agents; radiation; endocrine disrupters; indirect mutagenesis; threshold; new techniques for environmental mutagenesis studies; DNA methylation (enzymatic); structure activity relationship; chemoprevention of cancer; regulatory science. Genetic toxicology including risk evaluation for human health, validation studies on testing methods and subjects of guidelines for regulation of chemicals are also within its scope.