肿瘤生物标志物联合检测在胆囊癌诊断和预后中的价值

Q4 Medicine

中华肝胆外科杂志 Pub Date : 2019-10-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2019.10.007

Bo Yuan, Xiao-hui Fu, L. Yin, Wen-long Yu, Jian Liu, Xiang Wang, Yongjie Zhang

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引用次数: 0

摘要

目的分析血清肿瘤标志物CA19-9、CA242、CEA、CA724和CA125在胆囊癌诊断和预后中的临床价值。方法回顾性分析2009年3月至2013年12月收治的132例癌症胆囊癌患者术前血清CA19-9、CA242、CEA、CA724和CA125水平，进行敏感性比较，采用Kaplan-Meier生存表进行单因素生存分析，并比较log-rank方法的差异。Cox回归模型用于多变量生存分析。结果CA19-9、CA242、CA125、CEA和CA724的敏感性分别为67.4%、63.6%、42.4%、24.2%和22.7%。CA19-9和CA242的敏感性无显著差异（P>0.05），但无论CA19-9还是CA242，与CEA、CA724还是CA125相比，诊断敏感性均有显著差异（均P<0.05），与单纯CA242相比，CA242也有这种情况（均P>0.05）。单变量生存分析显示，CA19-9、CA242和CEA存在统计学显著差异（均P<0.05）。Cox回归表明，CA242是胆囊癌的独立预后因素。CA242与胆囊癌的组织学分级、淋巴结转移和TNM分期密切相关。结论CA19-9和CA242对胆囊癌的诊断有一定价值。CA242是胆囊癌的独立预后因素。关键词：胆囊肿瘤；CA19-9抗原；癌胚抗原；诊断，鉴别；预后；肿瘤标志物

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The value of combined detection of tumor biomarkers in the diagnosis and prognosis of patients with gallbladder carcinom

Objective To analyze the clinical value of serum tumor markers CA19-9, CA242, CEA, CA724 and CA125 in the diagnosis and prognosis of gallbladder carcinoma patients. Methods A retrospective analysis of the preoperative serum levels of CA19-9, CA242, CEA, CA724 and CA125 in 132 patients with gallbladder cancer admitted to Eastern Hepatobiliary Surgery Hospital from March 2009 to December 2013 for sensitivity comparison, Kaplan-Meier survival table was used for univariate survival analysis, and the log-rank method was compared for differences. The Cox regression model was used for multivariate survival analysis. Results The sensitivities of CA19-9, CA242, CA125, CEA and CA724 were 67.4%, 63.6%, 42.4%, 24.2% and 22.7%, respectively. There were no significant differences of the sensitivity between CA19-9 and CA242 (P>0.05). However, whether CA19-9 or CA242, there were significant differences of diagnostic sensitivity compared to CEA or CA724 or CA125 (all P 0.05). Similarly, CA242 also has such a situation when compared with CA242 alone (all P>0.05). Univariate survival analysis showed there were statistically significant differences in CA19-9, CA242, and CEA (all P<0.05). Cox regression suggested that CA242 is an independent prognostic factor for gallbladder carcinoma. CA242 is closely related to histological grade of gallbladder carcinoma, lymph node metastasis and TNM staging. Conclusions CA19-9 and CA242 have definite value in the diagnosis of gallbladder carcinoma. CA242 is an independent prognostic factor for gallbladder carcinoma. Key words: Gallbladder neoplasms; CA19-9 antigen; Carcinoembryonic antigen; Diagnosis, differential; Prognosis; Tumor marker

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来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.