SZJ-1207在小鼠血浆和脑中的UPLC-MS/MS分析及其在药代动力学研究中的应用

IF 1.7 4区化学 Q3 CHEMISTRY, ANALYTICAL

Acta Chromatographica Pub Date : 2023-01-16 DOI:10.1556/1326.2022.01102

D. Qi, Yingying Sun, Bingying Hu, Hai An, Haiyang Lin, Jinjun Fang, Yang Wei

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引用次数: 0

摘要

SZJ-1207是一种具有甾体结构的天然抗抑郁产品。它是一种新型的抗抑郁候选分子，其所有药代动力学性质尚未报道。本研究建立了一种准确、灵敏的UPLC-MS/MS方法，用于测定SZJ-1207在小鼠血浆和脑组织中的浓度。该结果为SZJ-1207作为一种潜在的抗抑郁药提供了药代动力学信息。

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UPLC-MS/MS analysis of SZJ-1207 in mouse plasma and brain and application in pharmacokinetic studies

SZJ-1207 is an antidepressant natural product with a steroidal structure extracted from Stephanotis mucronata. It is a novel antidepressant candidate molecule and all its pharmacokinetic properties have not been reported. In this pharmacokinetic study in mice following oral administration, an accurate and sensitive UPLC-MS/MS method was established and evaluated to measure SZJ-1207 concentrations in mouse plasma and brain samples. The results provide information regarding the pharmacokinetics of SZJ-1207 as a potential antidepressant.

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来源期刊

Acta Chromatographica 化学-分析化学

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

2.3 months

期刊介绍： Acta Chromatographica Open Access Acta Chromatographica publishes peer-reviewed scientific articles on every field of chromatography, including theory of chromatography; progress in synthesis and characterization of new stationary phases; chromatography of organic, inorganic and complex compounds; enantioseparation and chromatography of chiral compounds; applications of chromatography in biology, pharmacy, medicine, and food analysis; environmental applications of chromatography; analytical and physico-chemical aspects of sample preparation for chromatography; hyphenated and combined techniques; chemometrics and its applications in separation science.