跨性别人群的骨骼健康

IF 2 Q4 ENDOCRINOLOGY & METABOLISM

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2019-06-01 Epub Date: 2019-07-02 DOI:10.1007/s12018-019-09261-3

Micol S Rothman, Sean J Iwamoto

{"title":"跨性别人群的骨骼健康","authors":"Micol S Rothman, Sean J Iwamoto","doi":"10.1007/s12018-019-09261-3","DOIUrl":null,"url":null,"abstract":"It is well known that sex steroids, particularly estrogen, play a crucial role in the attainment and maintenance of peak bone density in all people. Transgender (trans) women have been frequently observed to have low bone density prior to initiation of gender-affirming hormone therapy, while trans men generally do not. With pharmacologic estrogen, many studies show improving bone density in trans women. With pharmacologic testosterone, bone density in trans men remains largely unchanged although androgens have indirect effects on bone health via changes in fat and lean mass. Much remains unknown about best practices to optimize bone health, interpret DXA scans and assess fracture risk in trans adults.","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"17 1","pages":"77-85"},"PeriodicalIF":2.0000,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709704/pdf/","citationCount":"0","resultStr":"{\"title\":\"Bone Health in the Transgender Population.\",\"authors\":\"Micol S Rothman, Sean J Iwamoto\",\"doi\":\"10.1007/s12018-019-09261-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"It is well known that sex steroids, particularly estrogen, play a crucial role in the attainment and maintenance of peak bone density in all people. Transgender (trans) women have been frequently observed to have low bone density prior to initiation of gender-affirming hormone therapy, while trans men generally do not. With pharmacologic estrogen, many studies show improving bone density in trans women. With pharmacologic testosterone, bone density in trans men remains largely unchanged although androgens have indirect effects on bone health via changes in fat and lean mass. Much remains unknown about best practices to optimize bone health, interpret DXA scans and assess fracture risk in trans adults.\",\"PeriodicalId\":45316,\"journal\":{\"name\":\"Clinical Reviews in Bone and Mineral Metabolism\",\"volume\":\"17 1\",\"pages\":\"77-85\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2019-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709704/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Reviews in Bone and Mineral Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12018-019-09261-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/7/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Reviews in Bone and Mineral Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12018-019-09261-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/7/2 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

摘要

众所周知，性类固醇，尤其是雌激素，在所有人达到和维持骨密度峰值方面起着至关重要的作用。在开始性别确认激素治疗之前，变性（trans）女性经常被观察到骨密度低，而变性男性通常不会。许多研究表明，使用药理学雌激素可以改善变性女性的骨密度。在使用药理学睾酮的情况下，跨性别男性的骨密度基本保持不变，尽管雄激素通过改变脂肪和瘦肉量对骨骼健康有间接影响。对于优化骨骼健康、解释DXA扫描和评估跨性别成人骨折风险的最佳实践，仍有许多未知之处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Bone Health in the Transgender Population.

It is well known that sex steroids, particularly estrogen, play a crucial role in the attainment and maintenance of peak bone density in all people. Transgender (trans) women have been frequently observed to have low bone density prior to initiation of gender-affirming hormone therapy, while trans men generally do not. With pharmacologic estrogen, many studies show improving bone density in trans women. With pharmacologic testosterone, bone density in trans men remains largely unchanged although androgens have indirect effects on bone health via changes in fat and lean mass. Much remains unknown about best practices to optimize bone health, interpret DXA scans and assess fracture risk in trans adults.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Clinical Reviews in Bone and Mineral Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Clinical Reviews in Bone and Mineral Metabolism is an international review journal aimed at integrating new information from both basic and clinical science into the context of clinical practice in the wide field of Bone and Mineral Metabolism. Although one purpose of the journal is to deal with the well-known classical aspects of bone and mineral physiology, the journal’s unique character is to highlight information about the advancing field of molecular medicine, which now finds linkages between this classical field and disease states that in the past were considered distinct. For example, cardiovascular disease and osteoporosis share many biochemical pathways. New molecular tools show common pathways with bone physiology and obesity, diabetes mellitus, and energy metabolism. The focus on the novel is a major aspect of this journal’s purpose. The rapid developments in the field needs to be represented in a comprehensive way in order to keep students, clinicians and researchers up-to date. In order to assure that all latest developments are covered, the journal publishes, not only, unsolicited reviews, but also invited reviews on most important topics as well.