Dupuytren病治疗的性别差异:临床试验的系统回顾和荟萃分析

IF 0.7 4区 医学 Q4 SURGERY
Plastic surgery Pub Date : 2024-08-01 Epub Date: 2022-12-04 DOI:10.1177/22925503221141707
Moaath M Saggaf, Kathy Liu, George Ho, Emily E Anastakis, Heather Baltzer
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引用次数: 0

摘要

目的:本研究的目的是评估Dupuytren病(DD)临床试验入组的性别差异、治疗效果和并发症。方法:检索3个数据库;Ovid MEDLINE, Ovid EMBASE和EBSCO CINAHL。纳入的研究是针对成年DD患者的临床试验。排除标准是非英语研究和其他研究设计。由两名独立审稿人完成摘要筛选、全文审查和数据提取。报告了对治疗疗效、耐受性和并发症的性别差异进行特别分析的研究的数量和百分比。研究人员对参加DD临床试验的女性参与者的比例进行了荟萃分析。结果:共筛选了3172篇参考文献,其中59篇研究被确定为全文综述。我们确定了28项临床试验,其中没有报告对性别差异的二次分析。只有2项试验讨论了并发症的性别差异,1项试验报告了耐受性的性别差异。meta分析中女性参与者的比例为19.5% [95% CI: 16.1-23.0%]。结论:性别差异在DD临床试验中发挥着至关重要的作用,但在临床试验中并未得到广泛的考虑。男性和女性在DD临床试验中的代表性并不相等。未来的研究应在临床试验的设计和分析中考虑性别差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex Difference in the Treatment of Dupuytren's Disease: A Systematic Review and Meta-Analysis of Clinical Trials.

Purpose: The aim of this study was to assess the sex differences in enrollment into clinical trials for Dupuytren's disease (DD), treatment efficacy, and complications. Methods: Three databases were searched; Ovid MEDLINE, Ovid EMBASE, and EBSCO CINAHL. Included studies were clinical trials on adult patients with DD. Exclusion criteria were non-English studies and other study designs. Two independent reviewers completed abstract screening, full-text review, and data extraction. The number and percentage of studies that reported ad hoc analyses for sex differences in treatment efficacy, tolerability, and complications were reported. A meta-analysis was performed on the proportion of female participants enrolled in clinical trials for DD. Results: A total of 3172 references were screened, and 59 studies were identified for full-text review. We identified 28 clinical trials for DD of which none reported secondary analyses for sex differences. Only 2 trials discussed sex differences in complications, and one trial reported sex differences in tolerability. The proportion of female participants in the meta-analysis was 19.5% [95% CI: 16.1-23.0%]. Conclusion: Sex differences in the clinical trials for DD are not widely considered in clinical trials despite their critical role. Males and females do not have equal representation in clinical trials for DD. Future studies should account for sex differences in the design and the analysis of clinical trials.

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来源期刊
Plastic surgery
Plastic surgery Medicine-Surgery
CiteScore
1.70
自引率
0.00%
发文量
73
期刊介绍: Plastic Surgery (Chirurgie Plastique) is the official journal of the Canadian Society of Plastic Surgeons, the Canadian Society for Aesthetic Plastic Surgery, Group for the Advancement of Microsurgery, and the Canadian Society for Surgery of the Hand. It serves as a major venue for Canadian research, society guidelines, and continuing medical education.
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