控制侵袭性淋巴瘤的异质性以进行精确治疗

IF 4.7 2区医学 Q1 ONCOLOGY

Annual Review of Cancer Biology-Series Pub Date : 2019-03-04 DOI:10.1146/ANNUREV-CANCERBIO-030518-055734

R. Young, J. Phelan, A. Shaffer, George W. Wright, D. Huang, R. Schmitz, Calvin A. Johnson, T. Oellerich, W. Wilson, L. Staudt

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引用次数: 17

摘要

弥漫性大B细胞淋巴瘤（DLBCL）的基因组分析揭示了这些侵袭性淋巴瘤的遗传和表型异质性。在某种程度上，这种异质性反映了不同遗传亚型的存在，这些亚型获得了体细胞遗传改变的特征性星座，从而汇聚在DLBCL表型上。同时，功能基因组筛选和蛋白质组学分析已经确定了DLBCL中协调致癌生存信号的多蛋白组装体。在这篇综述中，我们将这些最新的见解合并到一个统一的概念框架中，对DLBCL中精确药物试验的设计具有启示。

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Taming the Heterogeneity of Aggressive Lymphomas for Precision Therapy

Genomic analyses of diffuse large B cell lymphoma (DLBCL) are revealing the genetic and phenotypic heterogeneity of these aggressive lymphomas. In part, this heterogeneity reflects the existence of distinct genetic subtypes that acquire characteristic constellations of somatic genetic alterations to converge on the DLBCL phenotype. In parallel, functional genomic screens and proteomic analyses have identified multiprotein assemblies that coordinate oncogenic survival signaling in DLBCL. In this review, we merge these recent insights into a unified conceptual framework with implications for the design of precision medicine trials in DLBCL.

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来源期刊

Annual Review of Cancer Biology-Series Medicine-Oncology

CiteScore

14.50

自引率

1.30%

发文量

期刊介绍： The Annual Review of Cancer Biology offers comprehensive reviews on various topics within cancer research, covering pivotal and emerging areas in the field. As our understanding of cancer's fundamental mechanisms deepens and more findings transition into targeted clinical treatments, the journal is structured around three main themes: Cancer Cell Biology, Tumorigenesis and Cancer Progression, and Translational Cancer Science. The current volume of this journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, ensuring all articles are published under a CC BY license.