高迁移率组蛋白A2与肿瘤关系的研究进展

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-03-28 DOI:10.3760/CMA.J.CN115355-20190618-00256

Kai Li, Q. Fu

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引用次数: 0

摘要

高迁移率组蛋白A2（HMGA2）是一种本身不具有转录活性的非组蛋白，但它通过与染色质结合来改变结构，染色质反过来调节其他基因的转录，从而促进肿瘤的侵袭和转移。相关RNA基因可以调节HMGA2在肿瘤中的作用，肿瘤的侵袭性与上皮-间质转化（EMT）密切相关，EMT可以通过靶向HMGA2基因来治疗相关肿瘤。本文就HMGA2与肿瘤关系的研究进展作一综述。关键词：高迁移率组蛋白；分子靶向治疗；RNA；上皮-间充质转化

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Progress of the relationship between high mobility group protein A2 and tumors

High mobility group protein A2 (HMGA2) is a non-histone protein that does not have transcriptional activity by itself, but it changes its structure by binding to chromatin, which in turn regulates the transcription of other genes, thereby promoting tumor invasion and metastasis. The related RNA gene can regulate the role of HMGA2 in tumors, and the invasiveness of tumors is closely related to epithelial-mesenchymal transition (EMT), which can treat the related tumors by targeting HMGA2 gene. This article reviews the progress of the relationship between HMGA2 and tumors. Key words: High mobility group proteins; Molecular targeted therapy; RNA; Epithelial-mesenchymal transition

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.