男性雄激素受体基因CAG重复序列的国家差异:一个表格综述

Q3 Arts and Humanities

Mankind Quarterly Pub Date : 2021-03-01 DOI:10.46469/MQ.2021.61.3.4

L. Ellis, A. Hoskin, Hasan Buker

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引用次数: 1

摘要

作为雄激素作用的媒介，雄激素受体（AR）在建立生理和行为性别差异方面发挥着核心作用。AR基因含有CAG重复多态性，该多态性与雄激素对靶组织的作用强度有关，并与各种健康相关的疾病有关，尤其是前列腺癌症和不孕。一些研究还将AR CAG重复次数与行为和心理健康因素联系起来。本研究根据每项研究所在的国家提供了男性AR CAG重复次数的平均汇总表，从而使未来的研究能够将全国平均AR CAG反复次数与国家在身体、医学和行为特征方面的差异联系起来。调查结果汇总在两个表格中。第一个表列出了总共57826名研究参与者的187项研究中的每一项研究的结果，这些研究是根据每项研究的国家进行的。在第二个表中，第一个表的结果被浓缩为抽取样本的78个国家中每个国家的AR CAG重复次数的平均值。

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National Variations in CAG Repeats of Men’s Androgen Receptor Gene: A Tabulated Review

As the mediator of androgen actions, the androgen receptor (AR) plays a central role in establishing both physical and behavioral sex differences. The AR gene contains a CAG repeat polymorphism that is related to the strength of androgen actions on target tissues and that is correlated with various health-related conditions, especially prostate cancer and infertility. Some studies have also linked the number of AR CAG repeats with behavioral and mental health factors. The present study provides a tabulated summary of the average number of AR CAG repeats for males according to the countries in which each study was conducted, thereby allowing future research to correlate national average AR CAG repeats with national variations in physical, medical and behavioral traits. Findings are summarized in two tables. The first table lists results from each of 187 studies of a total of 57,826 research participants according to the country in which each study was conducted. In the second table, the results from the first table are condensed down to the average number of AR CAG repeats for each of the 78 countries from which samples were drawn.

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来源期刊

Mankind Quarterly Social Sciences-Anthropology

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Mankind Quarterly was founded as a quarterly journal of anthropology, in the broadest sense of "the science of man," in 1961. This was a time when the "study of man" had already diversified into physical anthropology, ethnography, quantitative cross-cultural research, archaeology and other subspecialties. Psychological and linguistic approaches were explored but the genetic study of population structure and population history was still in its infancy.