Anna Dominique Py Castro, M. A. A. Valencia, Jay Ron Padua
{"title":"一名患有局灶性脑炎的12岁菲律宾男孩的严重急性呼吸系统综合征冠状病毒2型嗜神经性","authors":"Anna Dominique Py Castro, M. A. A. Valencia, Jay Ron Padua","doi":"10.26815/acn.2022.00087","DOIUrl":null,"url":null,"abstract":"coronavirus (COVID-19) pandemic, there been reports of neurological manifestations of COVID-19, mostly in adults, albeit with a few cases described in children Several mechanisms have been proposed to explain how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may in-duce neurological damage. There is emerging supporting neurotropism and neuroinvasion in COVID-19, with polymerase chain reaction (PCR) of the cerebrospinal fluid positive results 13% of and pediatric of the discusses a case of focal encephalitis presenting with seizure and altered mental status following fever and mild respiratory illness associated with COVID-19. A notable aspect of this case was the detection of SARS-CoV-2 RNA in the CSF, despite its absence in two consecu-tive nasopharyngeal swab specimens. Written in-formed consent for publication was obtained from the","PeriodicalId":33305,"journal":{"name":"Annals of Child Neurology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"SARS-CoV-2 Neurotropism in a 12-Year-Old Filipino Boy with Focal Encephalitis\",\"authors\":\"Anna Dominique Py Castro, M. A. A. Valencia, Jay Ron Padua\",\"doi\":\"10.26815/acn.2022.00087\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"coronavirus (COVID-19) pandemic, there been reports of neurological manifestations of COVID-19, mostly in adults, albeit with a few cases described in children Several mechanisms have been proposed to explain how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may in-duce neurological damage. There is emerging supporting neurotropism and neuroinvasion in COVID-19, with polymerase chain reaction (PCR) of the cerebrospinal fluid positive results 13% of and pediatric of the discusses a case of focal encephalitis presenting with seizure and altered mental status following fever and mild respiratory illness associated with COVID-19. A notable aspect of this case was the detection of SARS-CoV-2 RNA in the CSF, despite its absence in two consecu-tive nasopharyngeal swab specimens. Written in-formed consent for publication was obtained from the\",\"PeriodicalId\":33305,\"journal\":{\"name\":\"Annals of Child Neurology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-05-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Child Neurology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26815/acn.2022.00087\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Child Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26815/acn.2022.00087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
SARS-CoV-2 Neurotropism in a 12-Year-Old Filipino Boy with Focal Encephalitis
coronavirus (COVID-19) pandemic, there been reports of neurological manifestations of COVID-19, mostly in adults, albeit with a few cases described in children Several mechanisms have been proposed to explain how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may in-duce neurological damage. There is emerging supporting neurotropism and neuroinvasion in COVID-19, with polymerase chain reaction (PCR) of the cerebrospinal fluid positive results 13% of and pediatric of the discusses a case of focal encephalitis presenting with seizure and altered mental status following fever and mild respiratory illness associated with COVID-19. A notable aspect of this case was the detection of SARS-CoV-2 RNA in the CSF, despite its absence in two consecu-tive nasopharyngeal swab specimens. Written in-formed consent for publication was obtained from the