炎症性肠病的生物治疗:复杂的机制和作用

L. O. Moreno, S. Fernández-Tomé, R. Abalo
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引用次数: 3

摘要

炎症性肠病(IBD)是一种需要终生服药的慢性疾病,其发病率在世界范围内呈上升趋势。目前还没有治愈IBD的方法,目前的治疗目标是控制炎症过程。大约三分之一的治疗患者对治疗没有反应,治疗难治性是常见的。因此,迫切需要单克隆抗体等药物治疗,并定期发布新的治疗指南。鉴于生物制剂目前在IBD治疗中的重要作用,我们在此简要回顾目前可用的主要生物治疗方法。此外,我们重点研究了最相关的生物制剂在IBD治疗中的作用机制,这些机制尚不完全清楚,但对于了解它们的治疗效果和可能产生的不良副作用无疑是重要的。为了更好地了解这些药物的作用机制,有必要进行进一步的研究,从而帮助我们了解如何提高其疗效和安全性。这些研究有望为个性化医疗铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biological Treatments in Inflammatory Bowel Disease: A Complex Mix of Mechanisms and Actions
Inflammatory bowel disease (IBD) is a chronic disease that requires lifelong medication and whose incidence is increasing over the world. There is currently no cure for IBD, and the current therapeutic objective is to control the inflammatory process. Approximately one third of treated patients do not respond to treatment and refractoriness to treatment is common. Therefore, pharmacological treatments, such as monoclonal antibodies, are urgently needed, and new treatment guidelines are regularly published. Due to the extremely important current role of biologics in the therapy of IBD, herein we have briefly reviewed the main biological treatments currently available. In addition, we have focused on the mechanisms of action of the most relevant groups of biological agents in IBD therapy, which are not completely clear but are undoubtfully important for understanding both their therapeutic efficacy and the adverse side effects they may have. Further studies are necessary to better understand the action mechanism of these drugs, which will in turn help us to understand how to improve their efficacy and safety. These studies will hopefully pave the path for a personalized medicine.
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