一线抗结核药物治疗药物监测的益处

Acta Medica Martiniana Pub Date : 2020-08-01 DOI:10.2478/acm-2020-0006

K. Pršo, N. Žideková, M. Dohál, I. Porvazník, M. Pršo, M. Kertys, J. Mokrý

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引用次数: 0

摘要

摘要结核病是一种空气传播的传染病，目前仍是一个巨大的全球健康问题。尽管新开发的药物不断获得批准，但在药物敏感的结核分枝杆菌菌株中使用一线抗结核药物似乎是合理的。治疗药物监测为测定血浆药物浓度以调整适当的剂量方案提供了一种有用的技术。在结核病治疗中，治疗药物监测有助于临床医生选择最佳治疗水平，这对个性化治疗至关重要。本综述旨在阐明一线抗结核药物治疗药物监测在常规临床实践中的应用。

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Benefits of Therapeutic Drug Monitoring of First Line Antituberculosis Drugs

Abstract Tuberculosis is an airborne infectious disease that remains a huge global health-related issue nowadays. Despite constant approvals of newly developed drugs, the use of first-line antituberculosis medicines seems reasonable in drug-susceptible Mycobacterium tuberculosis strains. Therapeutic drug monitoring presents a useful technique for the determination of plasma drug concentration to adjust appropriate dose regimes. In tuberculosis treatment, therapeutic drug monitoring is aiding clinicians in selecting an optimal therapeutic level, which is essential for the personalisation of therapy. This review is aimed at clarifying the use of therapeutic drug monitoring of the first-line antituberculosis drugs in routine clinical practice.

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来源期刊

Acta Medica Martiniana

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Acta Medica Martiniana is a medical scientific journal, first published in print form in December 2001. It is a continuation of the journal / almanac Folia Medica Martiniana (1971 - 1996). The journal‘s owner is the Jessenius Faculty of Medicine, Comenius University, Slovakia. Dissemination of research results and scientific knowledge from all areas of medicine and nursing. Stimulation, facilitation and supporting of publication activity for the young medical research and clinical generation. The contributions of young novice authors (PhD students and post-doctorials) are particularly welcome. Acta Medica Martiniana is an open-access journal, with a periodicity of publishing three times per year (Apr/Aug/Dec). It covers a wide range of basic medical disciplines, such as anatomy, histology, biochemistry, human physiology, pharmacology, etc., as well as all clinical areas incl. preventive medicine, public health and nursing. Interdisciplinary and multidisciplinary manuscripts, including papers from all areas of biomedical research, are welcome.