汉族女性癫痫患者性功能障碍与雌激素受体基因多态性的相关性研究

中华行为医学与脑科学杂志 Pub Date : 2019-10-20 DOI:10.3760/CMA.J.ISSN.1674-6554.2019.10.005

Li-Hong Tao, Xinjiang Zhang, Z. Duan, Yihui Liu

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引用次数: 0

摘要

目的探讨中国汉族癫痫患者性功能障碍（SD）与雌激素受体（ER）基因多态性的相关性。方法从扬州大学附属医院门诊和住院的112例已婚汉族癫痫患者中抽取120例作为对照组。WWE用抗癫痫药物（AED）治疗一年或一年以上。采用中国版女性性功能指数（FSFI）对受试者的性功能进行调查。采用化学发光法检测泌乳素（PRL）、卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）、孕酮（P）和睾酮（T）等性激素水平。应用聚合酶链式反应-限制性片段长度多态性（PCR-RFLP）检测ER基因多态性。采用卡方检验、t检验和二元逻辑回归进行统计分析。比较两组间性功能、性激素、ER基因型和等位基因频率的差异。并分析了SD与ER基因多态性的相关性。结果（1）SD在中国汉族WWE中的比例为70.5%（79/112），而对照组为24.2%（29/120）。WWE组血清泌乳素（PRL）水平显著高于对照组（t=2.072，P=0.039）结论ERαPvuII多态性可能与中国汉族WWE SD易感性有关，PvuII-CC基因型可能是WWE SD的危险基因型。关键词：癫痫；妇女；性功能障碍；性激素；雌激素受体

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The correlation of sexual dysfunction and estrogen receptor gene polymorphism in Chinese Han women with epilepsy

Objective To investigate the correlation between sexual dysfunction(SD)and estrogen receptor (ER) gene polymorphism in Chinese Han women with epilepsy (WWE). Methods A total of 112 married Chinese Han women with epilepsy were collected from outpatients and inpatients of the Affiliated Hospital of Yangzhou University, and 120 matched healthy women were taken as the control group.WWE were treated with antiepileptic drugs (AEDs) for one year or more.The Chinese version of female sexual function index (FSFI) was used to investigate the sexual function of the subjects.The chemiluminescence method was used to detect the sex hormones levels such as prolactin(PRL), follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), progesterone(P) and testosterone(T). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the ER gene polymorphism.Chi-square test, t-test and binary logistic regression were used for statistical analysis.The differences of the sexual function, sex hormone, ER genotype, and allele frequency were compared between the two groups.And the correlation between SD and ER gene polymorphism was analyzed. Results (1) The proportion of SD in Chinese Han WWE was 70.5%(79/112), while that was 24.2%(29/120) in the control group.The serum prolactin (PRL) level in the WWE group was significantly higher than that in the control group (t=2.072, P=0.039). (2) The allele frequencies of ER PvuII C and AluI A in the WWE group were significantly higher than those in the control group (P=0.001; P=0.001). (3) Binary logistic regression analysis showed that PvuII CC genotype and serum testosterone level were independently correlated with SD (OR=6.074, 95%CI: 1.257-29.352, P=0.025; OR=0.412, 95%CI: 0.201-0.842, P=0.015). Conclusion ERα PvuII polymorphism may be related to the susceptibility of SD in Chinese Han WWE, and PvuII CC genotype may be the risk genotype of SD in WWE. Key words: Epilepsy; Women; Sexual dysfunction; Sex hormone; Estrogen receptor

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中华行为医学与脑科学杂志

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期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.