新的抗炎三萜酯和糖苷。

Q2 Medicine

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2019-07-24 DOI:10.2174/1871523018666190724122406

N. Sultana, Muhammad Saleem Qazi, M. Kamal

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引用次数: 3

摘要

通过对白石桐属植物地上部分乙醇提取物的植物化学研究，分离出两种新的羊毛甾烷型三萜，羊毛石桐属5ene,24-乙基-3- o -β- d -葡萄糖吡喃葡萄糖苷(1)，羊毛石桐属5ene,24-乙基-3- o -β- d -葡萄糖吡喃葡萄糖苷(2)和新的熊甾型三萜-甲基lester, 12-熊甾-2,3,18,19-四醇，28乙酸(夜酪烯)(3)，以及7种已知的三萜，白桦碱，狼烷型三萜，蛇烯醇(4)。3β-羟基-28-β-乙酰氧基-5-油橄榄三萜(5)，α-醋酸amyrin (6)， α-amyrin(7)，醋酸lupeol (8)， 3β-羟基-24-no -urs-4,12,28-triene三萜(9)和熊果酸(10)。这些无色化合物的三萜结构是通过1H和13C- nmr数据，特别是通过二维1H, 13C相关实验的应用以及与文献数据的比较推断出来的。本研究对具有抗炎活性的天然新型三萜苷类化合物进行了分离和结构鉴定。

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New anti-inflammatory Triterpene Esters and glycosides from Alstonia scholaris.

Phytochemical studies on the ethanolic extract of aerial parts of Alstoniascholaris lead to the isolation of two new triterpenoid of the lanostanetype,lanosta 5ene,24-ethyl-3-O-β-D-glucopyranoside(1), lanosta,5ene,24-ethyl-3-O-β-D-glucopyranosideester(2)and new ursane type triterpenoidmethylester, 12-ursene-2,3,18,19-tetrol,28 acetate (nighascholarene)(3),together with seven known triterpenes, betuline,triterpeneof the lupane type, alstoprenyol(4), 3β-hydroxy-28-β-acetoxy-5-olea triterpene (5),α-amyrin acetate (6), α-amyrin (7), lupeol acetate (8), 3β-hydroxy-24-nor-urs-4,12,28-triene triterpene (9) and ursolic acid (l0). The triterpenoid structures of these colorless compounds were deduced from the 1H and 13C-NMR data, and in particular from the application of two-dimensional 1H, 13C correlation experiments as well as by comparison with reported literature data.This study deals with isolation and structural elucidation ofnaturalnewtriterpenoidestersandglycosides with anti-inflammatory activity.

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.