Application of blood purification in children with severe adenoviral disease

Severe hypoxia respiratory failure or acute respiratory distress syndrome, acute renal injury, liver function disorder, and multiple organ dysfunction syndrome caused by severe adenoviral disease have high mortality.Blood purification have become more widely available for acute renal injury, fluid overload, hyperlactacidemia, inflammatory reaction, coagulopathy and so on.The methods include renal replacement therapy(RRT) and therapeutic plasma exchange, usually combined with extracorporeal membrane oxygenation (ECMO). The appropriate blood purification strategy has not been available.Based on experience of RRT in acute renal injury, liver dysfunction, currently continuous renal replacement therapy/RRT technologies are reasonable used by personalized decision-making. Key words: Continuous renal replacement therapy; Therapeutic plasma exchange; Adenoviral disease; Adenoviral pneumonia; Critically ill; Children