预防和治疗肝细胞癌的草药衍生化合物。

IF 0.4 Q4 ONCOLOGY

Current Cancer Therapy Reviews Pub Date : 2022-05-19 DOI:10.2174/1573394718666220519115626

Z. Farzaneh, M. Farzaneh

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引用次数: 0

摘要

肝细胞癌是世界上第二大恶性肿瘤。在HCC中检测到各种信号通路的失调。最近的研究提出了一种用草药预防和治疗HCC的新方法。草药的抗癌作用可以在动物模型或HCC细胞系中进行评估。TGF-β、Wnt/β-catenin、SHH、Notch、Hippo、PI3K和VEGF等多种分子机制和信号通路已被发现可诱导和促进HCC的癌变。草药可以靶向HCC中的信号通路，并引发细胞凋亡、抑制增殖和肿瘤生长。使用草药的分子靶向治疗可能是治疗HCC的新策略。本研究提供了使用草药衍生化合物控制HCC的最新发现。

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Herbal medicine-derived compounds for the prevention and treatment of hepatocellular carcinoma..

Hepatocellular carcinoma (HCC) is the second malignancy worldwide. Dysregulation of various signaling pathways has been detected in HCC. Recent investigations have suggested a new approach for the prevention and treatment of HCC with herbal drugs. The anticancer effects of herbal drugs can be evaluated in animal models or HCC cell lines. Various molecular mechanisms and signaling pathways such as TGF-β, Wnt/β-catenin, SHH, Notch, Hippo, PI3K, and VEGF have been found to induce and promote carcinogenesis of HCC. Herbal drugs can target the signaling pathways in HCC and trigger apoptosis, suppress proliferation, and tumor growth. Molecularly targeted therapies using herbal drugs can be novel therapeutic strategies against HCC. This study provides the latest findings on using herbal medicine-derived compounds in the control of HCC.

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来源期刊

Current Cancer Therapy Reviews ONCOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Current Cancer Therapy Reviews publishes frontier reviews on all the latest advances in clinical oncology, cancer therapy and pharmacology. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cancer therapy.