Acute Psychosis Associated with Septo-Optic Dysplasia (De Morsier Syndrome)

Background: Septo-optic dysplasia (SOD), a variable combination of abnormalities of cerebral midline structures, is a clinically heterogeneous syndrome. Psychiatric symptoms in SOD were implicated in one case due to abnormal regulation of neuroendocrine structures.Objective: Discussion of a case of SOD associated with psychosis and depression, exploring the role of anatomical and endocrine abnormalities in producing psychiatric symptoms.Methods: Literature was reviewed on the PubMed, Medline, and Web of Science. One case of SOD with psychosis was reported in 2008.Conclusions: Disruption of complex neural pathways, including the septum pellucidum and other limbic structures may have been involved in the psychiatric disturbances in this case. Further reporting of similar cases is needed for more understanding of these associations.