Importance of time in traditional medicine: a case of three plants use of Togolese pharmacopoeia

Introduction. The effectiveness of folk medicine has been demonstrated by several studies. However, the chrono-toxicological aspect is barely addressed. Objective. The present study, conducted in the region of Kara in Togo, assessed the importance of the factor "time" in the use of 3 plants commonly used in traditional pharmacopoeia: Sarcocephalus latifolius, Jatropha multifida, and Blighia sapida. Material and methods. The methodology was based on ethnobotanical surveys, semi-structured individual interviews of 36 traditional healers using the three plants. Analysis of these data was based on consensus values (CV), and use values (UV). A chrono-toxicological assessment of their hydro-alcoholic extracts permitted to determine the impact of administration time on liver and kidney of Swiss albinos mice male. Results. The most used organs by traditional healers were roots (UV=0.62) for S. latifolius, bark (UV=0.53) for B. sapida, and leaves (0.66) for J. multifida. Malaria was the most treated disease with S. latifolius (CV=0.44), and J. multifida (CV=0.5). Haemorrhoid was cured with B. sapida (CV=0.28). Plant parts were harvested mainly in the morning (VC≥ 0.55). The most recommended dosing period was morning - evening for S. latifolius (VC=0.70), and B. sapida (VC=0.70), and only in the morning for J. multifida (VC=0.50). The hydro-alcoholic extracts administration of S. latifolius at 12H increased significantly mice liver weight. There was also a significant increase in liver weight in mice treated morning and evening by a hydro-alcoholic extract of J. multifida. Conclusion. Checking account of harvest time, and/or administration of phytomedicines will contribute to improve significantly the effectiveness of traditional medicine.