堇叶Tinospora叶提取物及其负载的植物体对米非司酮诱导的多囊卵巢综合征（PCOS）大鼠的激素调节作用——体内研究

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2023-08-20 DOI:10.1080/10496475.2023.2248050

S. Masilamani, Priya Chokkalingam, Meera B, R. Hari, M. P

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引用次数: 0

摘要

摘要研究了天花粉叶提取物（ELETC）及其负载的植物激素体（nELETC）对米非司酮诱导的雌性多囊卵巢综合征（PCOS）大鼠激素水平变化的影响。米非司酮（4 mg kg−1 b.w.）给雌性大鼠，持续8天，以发展为多囊卵巢综合征，然后通过延长的发情周期来检测。PCOS大鼠的治疗方案包括200 mg kg−1 b.w.的ELETC和nELETC，每天口服，持续28天。激素测试显示二甲双胍是一种良好的对照。结果表明，ELETC和nELETC可作为治疗PCOS的替代方案，以减少高胰岛素血症、胰岛素抵抗和高雄激素血症的并发症。

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Hormonal Regulatory Impacts of Tinospora cordifolia Leaf Extract and Its Loaded Phytoniosome on Mifepristone-Induced Polycystic Ovarian Syndrome (PCOS) Rats – In Vivo Studies

ABSTRACT The effects of ethanolic leaf extract of Tinospora cordifolia (ELETC) and its loaded phytoniosomes (nELETC) on altered hormonal levels in female polycystic ovarian syndrome (PCOS) rats induced by mifepristone were investigated. Mifepristone (4 mg kg−1 b.w.) was given daily to female rats for 8 days to develop PCOS, which was then detected by a protracted estrous cycle. The treatment regimen for the rats with PCOS consisted of 200 mg kg−1 b.w. of ELETC and nELETC administered orally every day for 28 days. Hormone tests showed that metformin acted as a favorable control. Results demonstrated that ELETC and nELETC may be used as therapeutic alternatives for treating PCOS to decrease complications of hyperinsulinemia, insulin resistance, and hyperandrogenism.

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.