阿德福韦治疗拉米夫定耐药乙型肝炎

IF 1.3 4区医学 Q4 INFECTIOUS DISEASES

Antiviral Therapy Pub Date : 2022-02-01 DOI:10.1177/13596535211067605

Rebecca Roediger, Elizabeth Smyth, D. Dieterich

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引用次数: 3

摘要

约翰·马丁开发的核苷酸类似物阿德福韦是治疗慢性乙型肝炎的一个重大突破。在阿德福韦之前，乙型肝炎的治疗仅限于两种治疗方式，一种是干扰素，它具有显著的副作用，对少数患者有效，或拉米夫定，其短期使用无持久效果，长期使用耐药率高。阿德福韦被发现在抑制病毒复制和解决与乙型肝炎相关的肝脏炎症方面有效，只有罕见的耐药性。在这篇文章中，我们感谢约翰·马丁对科学和医学的贡献，因为我们回顾了阿德福韦的里程碑式试验，它开创了乙型肝炎治疗的新时代。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Adefovir for lamivudine-resistant hepatitis B

Adefovir, a nucleotide analog developed by John Martin, was a major breakthrough in the treatment of chronic Hepatitis B. Prior to adefovir, Hepatitis B treatment was limited to two therapeutic modalities, either interferon, which carried significant side effects and was efficacious in a minority of patients, or lamivudine which showed no durable effects with short-term use and a high rate of resistance with long-term use. Adefovir was found to be effective in suppressing viral replication and in resolving the hepatic inflammation associated with hepatitis B with only rare instances of resistance. In this article, we appreciate John Martin’s contribution to science and medicine as we review the landmark trials of adefovir that brought forth a new era of treatment of Hepatitis B.

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来源期刊

Antiviral Therapy 医学-病毒学

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.