5-ALA与5-ALA己基酯比活性的比较实验研究

Q3 Medicine

Biomedical Photonics Pub Date : 2018-10-18 DOI:10.24931/2413-9432-2018-7-3-43-46

R. Yakubovskaya, A. Pankratov, E. Filonenko, E. Lukyanets, V. Ivanova-Radkevich, A. Trushin, A. Kaprin

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引用次数: 3

摘要

对基于5-氨基乙酰丙酸（5-ALA）及其己基酯（5-ALA-HE）的药物的比活性进行了比较实验研究。已经估计了当滴注不同浓度的药物溶液时，它们在兔膀胱的健康组织中诱导光活性原卟啉IX合成的能力。研究表明，5-ALA-HE导致PPIX在兔膀胱上皮中的诱导和积累，其浓度远低于5-ALA。因此，与对照组相比，通过在兔膀胱中滴注浓度仅为0.0001%（荧光强度2.20±0.60a.u.）的5-ALA HE溶液，以及仅在使用浓度为0.3%（荧光强度2.60±1.02a.u。

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Comparative experimental study of 5-ALA and 5-ALA hexyl ester specific activity

A comparative experimental study of the specific activity of drugs based on 5-aminolevulinic acid (5-ALA) and its hexyl ester (5-ALA HE) was carried out. Their ability to induce the synthesis of photoactive protoporphyrin IX in the healthy tissues of the rabbit bladder when instilling the drug solutions at various concentrations has been estimated. It was shown that 5-ALA HE results in the induction and accumulation of PPIX in the rabbit bladder epithelium at much lower concentrations than 5-ALA. Thus, a significant increase in the fluorescence intensity in comparison with the control was achieved by instillation of 5-ALA HE solution in the rabbit’ bladder at a concentration of only 0.0001% (fluorescence intensity 2.20±0.60 a.u.), and for 5-ALA – only when using a solution at a concentration of 0.3% (fluorescence intensity 2.60±1.02 a.u.).

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来源期刊

Biomedical Photonics Medicine-Surgery

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The main goal of the journal – to promote the development of Russian biomedical photonics and implementation of its advances into medical practice. The primary objectives: - Presentation of up-to-date results of scientific and in research and scientific and practical (clinical and experimental) activity in the field of biomedical photonics. - Development of united Russian media for integration of knowledge and experience of scientists and practitioners in this field. - Distribution of best practices in laser medicine to regions. - Keeping the clinicians informed about new methods and devices for laser medicine - Approval of investigations of Ph.D candidates and applicants.