HBSAG定量检测在HBEAG阴性慢性乙型肝炎中的临床意义

Q4 Medicine
M. Dimzova, M. Bosilkovski, M. Gasheva, Boban Toshevski, Biljana Petreska, Marija Cvetkova, D. Jakimovski
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引用次数: 0

摘要

背景:HBsAg的定量提供了不同且互补的信息,有助于确定慢性乙型肝炎病毒感染的不同阶段,评估和随访肝病进展以及治疗个体化。目的:探讨HBeAg阴性慢性肝炎(CHB)患者定量HBsAg(qHBsAg)的临床意义及其与血清丙氨酸氨基转移酶(ALT)、定量HBVDNA和肝纤维化的关系。受试者和方法:本研究包括53例HBeAg阴性慢性乙型肝炎的治疗初期患者。所有患者都接受了完整的实验室和血清学检测,HBVDNA和HBs抗原的定量。用弹性成像测量肝脏硬度。在一个时间点记录患者的人口统计学特征、病毒和生化标志物。结果:qHBsAg与ALT的相关性分析显示,qHBsAg/HBVDNA的相关系数R=0.42,P<0.05。qHBsAg与肝纤维化呈正相关,R=0.08,p>0.05。血清HBsAg水平对ALT水平的影响大于HBVDNA水平(R=0.15,p>0.05)。结论:ALT值越高、肝纤维化评分越高,qHBsAg越高;qHBsAg可反映血清HBV DNA水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The clinical significance of quantitative HBSAG in patients with HBEAG negative chronic hepatitis B
Background: The quantification of HBsAg provides different and complementary information that helps in determination of the different phases of chronic hepatitis B viral infection, evaluation and follow-up of liver disease progression as well as in treatment individualization.Aim: To evaluate the clinical significance of quantitative HBsAg (qHBsAg) in patients with HBeAg negative chronic hepatitis (CHB) and its correlation with the serum levels of alanine aminotransferase (ALT), quantitative HBV DNA and liver fibrosis.Subjects and Methods: The study included 53 treatment naïve patients with HBeAg negative chronic hepatitis B. All patients underwent complete laboratory and serology testing, quantification of HBV DNA and HBs antigen. The liver stiffness was measured with elastography. Patients’ demographic characteristics, viral and biochemical markers were recorded at one point of time.Results: Correlation analysis between the qHBsAg and ALT showed an significant, positive correlation between the parameters for R=0.42 and p<0.05; there was statistically non-significant positive correlation for R=0.25 and p>0.05 between qHBsAg and HBV DNA. There was a positive correlation between qHBsAg and liver fibrosis for R=0.08 and p>0.05. The serum levels of HBsAg had greater impact on the serum levels of ALT compared to that of HBV DNA for R=0.15 and p>0.05.Conclusion: Patients with higher ALT values and higher liver fibrosis score have higher qHBsAg; qHBsAg can reflect the serum HBV DNA levels.
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来源期刊
Acta Medica Saliniana
Acta Medica Saliniana Medicine-Medicine (all)
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