Wnt信号通路在口腔发育中的研究进展及临床应用前景

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Organogenesis Pub Date : 2019-09-04 DOI:10.1080/15476278.2019.1656996

Xi Lu, Jun Yang, Shouliang Zhao, Shangfeng Liu

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引用次数: 11

摘要

Wnt信号通路在胚胎发生、组织稳态和伤口修复等生物发育过程中被广泛研究。众所周知，Wnt信号通路在牙齿发育过程中起着重要作用。本文总结了Wnt信号通路在牙齿起始、牙冠形态发生、牙根形成过程中的作用，并讨论了Wnt调节剂的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances of Wnt signalling pathway in dental development and potential clinical application

ABSTRACT Wnt signalling pathway is widely studied in many processes of biological development, like embryogenesis, tissue homeostasis and wound repair. It is universally known that Wnt signalling pathway plays an important role in tooth development. Here, we summarized the function of Wnt signalling pathway during tooth initiation, crown morphogenesis, root formation, and discussed the therapeutic potential of Wnt modulators.

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.