Subacute stent thromboses in marijuana user associated with isolated protein S deficiency: Thirteenth month of the famine

We present the case of a young professional male, marijuana user who experienced subacute stent thromboses following percutaneous coronary intervention. We identified that he also had a protein S deficiency when we investigated the medical causes of procoagulant conditions. The patient was subjected to a surgical revascularization and began direct oral anticoagulant combined with antiplatelet agents to prevent recurrent thrombotic events. There is no proven way of revascularization in these cases, and antithrombotic medications are ineffective in preventing recurrent ischemia episodes, necessitating more research to determine definitive therapeutic methods for these subsets of cases.