基于TLR4激动剂的新型疫苗佐剂研究进展

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2019-08-31 DOI:10.3760/CMA.J.ISSN.0254-5101.2019.08.013

Qiao Li, Yuepeng Wang, Yusen Zhou, Z. Kou

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引用次数: 1

摘要

toll样受体4 (TLR4)是目前toll样受体家族中被广泛研究的Ⅰ型跨膜蛋白。TLR4配体包括存在于革兰氏阴性菌外膜的脂多糖(LPS)和脂多糖衍生物单磷酰脂质A (MPLA)。TLR4激动剂作为复合佐剂的主要成分或与其他tlr激动剂联合使用，已被广泛应用于各种疫苗的佐剂中，在疫苗开发中显示出巨大的潜力。本文综述了基于TLR4激动剂的新型疫苗佐剂的发现、应用、特点及前景，旨在为佐剂的合理使用和进一步开发提供参考。关键词:佐剂;免疫增强药;TLR4;疫苗

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Advances in novel vaccine adjuvants based on TLR4 agonists

Toll-like receptor 4 (TLR4), a type Ⅰ transmembrane protein, has been extensively studied in the Toll-like receptor family at present. TLR4 ligands include lipopolysaccharides (LPS) present in the outer membrane of gram-negative bacteria and monophosphoryl lipid A (MPLA) which is a derivative of LPS. TLR4 agonists, alone, as a major component of compound adjuvants or in combination with other TLRs agonists, have been widely used as adjuvants in various vaccines and demonstrated great potential in vaccine development. This review addressed the discovery, application, features and prospect of novel vaccine adjuvants based on TLR4 agonists, aiming to provide reference for rational use of adjuvants and further development. Key words: Adjuvant; Immunostimulant; TLR4; Vaccine

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.