亚致死剂量棉酚对雄性家兔血液学特性和生化代谢产物的影响

IF 0.8 4区农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE

World Rabbit Science Pub Date : 2019-12-23 DOI:10.4995/wrs.2019.11253

T. Ramadan, A. Rashad

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引用次数: 0

摘要

本研究的目的是研究每隔一天给药两次亚致死剂量棉酚（4和20 mg/kg体重）对雄兔血浆中某些血液学、生化、酶和电解质特性以及氨基酸和脂肪酸的影响。实验持续16周，分为两个阶段：1）给药期；给家兔实验剂量的GOS，持续8wk；和2）恢复期；允许兔子8周从血浆中完全停药。结果表明，与对照组相比，低水平棉酚使血红蛋白、平均红细胞血红蛋白和白细胞增加（P<0.01）。在两个实验阶段，低GOS剂量使血浆总蛋白增加（P<0.01）。同样，在恢复期，高剂量GOS使葡萄糖浓度增加（P<0.01）。高剂量GOS治疗组血清天冬氨酸转氨酶和丙氨酸转氨酶升高（P<0.01）。低剂量GOS仅使恢复期血浆Na+浓度升高（P<0.01）。结果显示，在治疗阶段，总必需氨基酸（EAA）和EAA/非EAA比率没有受到剂量依赖性的影响，血浆脯氨酸除外，高GOS剂量使其与非EAA一起增加（P<0.01）。此外，GOS给药不会以剂量依赖的方式影响总不饱和脂肪酸（USFA）、总饱和脂肪酸和SFA/USFA比率。总之，棉酚治疗以剂量依赖的方式影响家兔血液学参数和血浆生化特性。

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Effects of sublethal doses of gossypol on haematological properties and biochemical metabolites of male rabbit

The purpose of this study was to investigate the effects of two sublethal doses of gossypol (GOS) (4 and 20 mg/kg of body weight), administered every other day, on some haematological, biochemical, enzymatic and electrolytic properties and amino and fatty acids in male rabbit blood plasma. The experiment lasted for 16 wk and included two phases: 1) administration period; rabbits were given the experimental doses of GOS for 8 wk; and 2) recovery period; rabbits were allowed 8 wk for complete withdrawal of drugs from the plasma. Results showed that low levels of gossypol increased ( P <0.01) haemoglobin, mean corpuscular haemoglobin and white blood cells compared to control. Plasma total protein was increased ( P <0.01) by the low GOS dose in both experimental phases. Likewise, glucose concentration was increased ( P <0.01) by the high GOS dose during the recovery period. Aspartate aminotransferase and alanine aminotransferase enzymes were increased ( P <0.01) by the high dose of GOS treatment only. Low GOS dose increased ( P <0.01) blood plasma Na+ concentration in the recovery period only. Results revealed that total essential amino acids (EAA), and EAA/non-EAA ratio were not affected in a dose-dependent manner during the treatment phase expect for plasma proline, which was increased along with non-EAA ( P <0.01) by high GOS dose. Additionally, GOS administration did not affect total unsaturated fatty acids (USFA), total saturated fatty acids (SFA) and SFA/USFA ratio in a dose-dependent manner. In conclusion, Gossypol treatment affected rabbit haematological parameters and biochemical properties of blood plasma in a dose-dependent manner.

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来源期刊

World Rabbit Science 农林科学-奶制品与动物科学

CiteScore

1.70

自引率

25.00%

发文量

审稿时长

>36 weeks

期刊介绍： World Rabbit Science is the official journal of the World Rabbit Science Association (WRSA). One of the main objectives of the WRSA is to encourage communication and collaboration among individuals and organisations associated with rabbit production and rabbit science in general. Subject areas include breeding, genetics, production, management, environment, health, nutrition, physiology, reproduction, behaviour, welfare, immunology, molecular biology, metabolism, processing and products. World Rabbit Science is the only international peer-reviewed journal included in the ISI Thomson list dedicated to publish original research in the field of rabbit science. Papers or reviews of the literature submitted to World Rabbit Science must not have been published previously in an international refereed scientific journal. Previous presentations at a scientific meeting, field day reports or similar documents can be published in World Rabbit Science, but they will be also subjected to the peer-review process. World Rabbit Science will publish papers of international relevance including original research articles, descriptions of novel techniques, contemporaryreviews and meta-analyses. Short communications will only accepted in special cases where, in the Editor''s judgement, the contents are exceptionally exciting, novel or timely. Proceedings of rabbit scientific meetings and conference reports will be considered for special issues. World Rabbit Science is published in English four times a year in a single volume. Authors may publish in World Rabbit Science regardless of the membership in the World Rabbit Science Association, even if joining the WRSA is encouraged. Views expressed in papers published in World Rabbit Science represent the opinion of the author(s) and do not necessarily reflect the official policy of the WRSA or the Editor-in-Chief.