癫痫患者MDR1基因多态性与苯妥英药代动力学

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

Bahrain Medical Bulletin Pub Date : 2017-03-01 DOI:10.12816/0047438

A. Alhazzani, Murali Munisamy, G. Karunakaran

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引用次数: 2

摘要

29癫痫被认为是主要的公共卫生问题之一，可能造成严重的心理和身体后果，包括精神健康失调、外伤和过早死亡1。癫痫是一种慢性致残性神经系统疾病，影响全球约1%的人口，特别是在发展中国家1,2。尽管大多数癫痫患者预后良好，但仍有大约20%至30%的癫痫患者在接受多种抗癫痫药物(aed)干预后仍不能保持无发作状态3,4,5。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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MDR1 Gene Polymorphism and Phenytoin Pharmacokinetics in Epilepsy

29 Epilepsy is considered one of the major public health problems and could have serious psychological and physical consequences, including mental health disorders, traumatic injury and premature death1. Epilepsy is a chronic and disabling neurologic disorder and affects approximately 1% of the population globally, especially in developing countries1,2. Although good prognosis has been seen in most patients with epilepsy, approximately 20% to 30% of patients with epilepsy do not remain seizure free despite the intervention of multiple antiepileptic drugs (AEDs)3,4,5.

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来源期刊

Bahrain Medical Bulletin MEDICINE, GENERAL & INTERNAL-

CiteScore

0.60

自引率

50.00%

发文量

期刊介绍： The Bahrain Medical Bulletin is published every three months appearing in March, June, September and December. It is indexed in the World Health Organization Index Medicus for Eastern Mediterranean Region (IMEMRI), Extramed of the United Kingdom and International Serial Data System of France. Everything we publish is freely available online throughout the world, for you to read, download, copy, distribute, and use (with attribution) any way you wish. No permission required.