MMP-2、MMP-9、TIMP-1和TIMP-2血清水平对癌症患者化疗后肿瘤完全反应的预测作用

IF 2.1 4区 医学 Q2 SURGERY
Kayhan Ozdemir, Ismail Zengin, G. Guney Eskiler, H. Kocer, A. Ozkan, T. Demiray, Elif Özözen Şahin
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引用次数: 3

摘要

摘要目的研究癌症患者血清MMPs和TIMPs水平,以预测新辅助化疗前后的疗效。BC是女性最常见的癌症,MMPs负责器官发生过程中ECM蛋白的分解,TIMP限制了MMPs对ECM的破坏。然而,MMPs和TIMPs在BC患者治疗反应中的预测作用尚未确定。方法本研究包括96例BC患者(34例新辅助治疗,62例手术治疗)和35名健康人。ELISA用于测定BC患者血清样品中MMP-2、MMP-9、TIMP-1和TIMP-2的水平。结果所有BC患者在诊断时和化疗后MMP-9和TIMP-2的平均水平均显著升高,而MMP-2在诊断时显著降低。新辅助组和手术治疗组化疗后TIMP-1水平以及HER2和ER状态仅有显著差异。此外,化疗后BC患者血清MMP-2和MMP-9水平与肿瘤大小和转移淋巴结呈负相关。结论高MMP-9和TIMP-2水平的BC患者可用于预测肿瘤的分期和对化疗的CR,化疗后血清TIMP-1水平的升高可能与更好的化疗反应有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients
Abstract Objective We investigated the serum levels of MMPs and TIMPs in breast cancer (BC) patients to predict the response rate to/after treatment with or without neoadjuvant chemotherapy. BC is the most common cancer in women and MMPs are responsible for the breakdown of ECM proteins during organogenesis and TIMPs are restricted the ECM destruction by MMPs. However, the predictive role of MMPs and TIMPs in the treatment response of BC patients has not identified. Methods This study consisted of 96 BC patients (34 neoadjuvant treatment and 62 surgically treated) and 35 healthy individuals. ELISA was used to determine the level of MMP-2, MMP-9, TIMP-1, and TIMP-2 from serum samples of BC patients. Results The mean levels of MMP-9 and TIMP-2 were significantly increased in all BC patients at diagnosis and after chemotherapy, but MMP-2 was considerably lower at diagnosis. There was only a significant difference in the TIMP-1 levels after chemotherapy as well as HER2 and ER status in the neoadjuvant and surgically treated group. Additionally, MMP-2 and MMP-9 serum levels negatively correlated with tumor size and metastatic lymph nodes in BC patients after chemotherapy. Conclusions BC patients with high levels of MMP-9 and TIMP-2 can be used to predict the stage of the tumor and CR to chemotherapy and higher TIMP-1 serum level after chemotherapy could be related to better response to chemotherapy.
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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