聚六亚甲基胍水凝胶及山楂提取物在热烧伤模拟中的创面愈合活性

Q4 Chemistry

Mongolian Journal of Chemistry Pub Date : 2022-12-23 DOI:10.5564/mjc.v23i49.2049

S. Stelmakh, O. Ochirov, M. Grigor’eva, A. Tykheev, S. Lebedeva, V. Okladnikova, S. Zhamsaranova

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引用次数: 0

摘要

介绍了在实验室动物（大鼠）热烧伤模型条件下，基于聚六亚甲基胍盐酸盐和厚叶Bergenia提取物水凝胶的组合物的伤口愈合活性的研究结果。研究发现，该成分影响总抗氧化和白细胞活性的变化，使这些指标正常化。切片的形态学分析表明，在聚六亚甲基胍水凝胶组合物和厚叶B.crassifolia提取物的影响下，愈合进行得比对照组更为强烈，表现为白细胞坏死结痂厚度更小，上皮化加速，皮肤缺损完全闭合。

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Wound-healing activity of polyhexamethyleneguanidine hydrochloride hydrogel and extract of Bergenia crassifolia on thermal burn simulation

The results of a study of the wound healing activity of a composition based on the hydrogel of polyhexamethylene guanidine hydrochloride and Bergenia crassifolia extract, under conditions of modeling thermal burns in laboratory animals (rats), are presented. It was found that the composition affects the change in the summary antioxidant and leukocyte activity towards the normalization of these indicators. Morphological analysis of the slices showed that, under the influence of a polyhexamethylene guanidine hydrogel composition and B.crassifolia extract, healing proceeds more intensively than in the control group and is manifested by a smaller thickness of the leukocyte-necrotic scab, accelerated epithelization, and complete closure of the skin defect.

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来源期刊

Mongolian Journal of Chemistry Materials Science-Materials Chemistry

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

20 weeks