具有抗菌活性的1,2,4-三嗪和1,2,5-恶二嗪新衍生物的合成

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-09-25 DOI:10.1155/2019/2326514

H. Hashem, A. Abo-Bakr

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引用次数: 9

摘要

1,2,4-三嗪和1,2,5-恶二嗪衍生物2 - 12由苯基肼或盐酸羟胺处理后的1,3-恶唑酮(1)得到。氯三嗪衍生物3与不同的试剂进行缩合反应，得到新的四氮唑-三嗪和三氮唑-喹唑啉酮衍生物。1,2,5-恶二嗪已被用作融合吡唑-恶二嗪衍生物的合成物。根据微量分析和光谱数据建立了化合物的结构。对部分新化合物的抗菌活性进行了评价。

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Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity

1,2,4-Triazine and 1,2,5-oxadiazine derivatives 2–12 were obtained from treated 1,3-oxazolone (1) with phenyl hydrazine or hydroxylamine hydrochloride. Chlorotriazine derivative 3 undergoing condensation reactions with different reagents produced new fused tetrazolo-triazine and triazino-quinazolinone derivatives. 1,2,5-Oxadiazine has been used as a synthon for the fused pyrazolo-oxadiazine derivative. The constitution of the prepared compounds was built up based on microanalytical and spectral data. Some of the new compounds were assessed for their antimicrobial activity.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.