penioctadectrienoic A:来自内生真菌青霉J70的新聚酮

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2023-08-03 DOI:10.25135/rnp.397.2304.2752

Siwen Niu, Juan Wang, Jianlin He, Xin Liu, Bi-hong Hong, Miao-Ling Yu

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引用次数: 0

摘要

：对从日本金丝桃鲜叶中分离出的真菌Penicillium pinophilum J70的大米固体发酵培养物进行化学检查，分离出一种新的聚酮，即青霉烯十碳三烯酸A（1），以及两种已知的化合物（2和3）。新代谢物1的结构是在广泛的光谱分析（NMR和HRESIMS数据）的基础上，结合用于绝对构型分配的改良Mosher方法来解析的。评估所有分离的代谢物对ECA-109的细胞毒性活性、对脂多糖（LPS）刺激的RAW264.7细胞中NO产生的抗炎活性以及对金黄色葡萄球菌ATCC 29213的抗菌活性。结果，化合物1-3在20μM浓度下表现出中等的抗炎作用，抑制率在44.5%-60.7%之间。此外，化合物1表现出较弱的抗菌作用，MIC值为32µg/mL。

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Penioctadecatrienoic A: A New Polyketide from Endophytic Fungus Penicillium pinophilum J70

: Chemical examination of the rice solid fermented cultures of the fungus Penicillium pinophilum J70 isolated from the fresh leaves of Hypericum japonicum Thumb led to the isolation of one new polyketide, namely penioctadecatrienoic A ( 1 ), together with two known compounds ( 2 and 3 ). The structure of the new metabolite 1 was resolved on the basis of extensive spectroscopic analysis (NMR and HRESIMS data), in association with the modified Mosher's method for the absolute configurational assignment. All isolated metabolites were evaluated for their cytotoxic activity against ECA-109, the anti-inflammatory activity against NO production in lipopolysaccharides (LPS) stimulated RAW264.7 cells, and the antibacterial activity on Staphylococcus aureus ATCC 29213. As a result, compounds 1‒3 showed moderately anti-inflammatory effects with the inhibitory rates ranging from 44.5% to 60.7% at the concentration of 20 μ M. In addition, compound 1 exhibited weakly antibacterial effect with an MIC value of 32 µ g/mL.

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.