自噬对放射敏感性的影响

中华放射肿瘤学杂志 Pub Date : 2019-12-15 DOI:10.3760/CMA.J.ISSN.1004-4221.2019.12.017

Guanchu Song, Dan Liu, Genyan Guo

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引用次数: 0

摘要

自噬广泛存在于真核生物中，它利用溶酶体降解受损的细胞器或蛋白质，维持细胞内环境的稳定并提供能量。它还可以通过自噬相关基因和信号通路参与肿瘤细胞的生长、增殖和凋亡。放射治疗是癌症的主要治疗方法之一，而肿瘤细胞往往具有辐射耐药性，这降低了临床疗效。先前的研究表明，自噬与肿瘤细胞的放射敏感性有关，但结论不同。本文综述了自噬对肿瘤细胞放射增敏的不同影响。关键词：自噬；肿瘤/放疗

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Effects of autophagy on radiosensitivity

Autophagy extensively exists in eukaryotes, which utilizes lysosomes to degrade the damaged organelles or proteins, maintain the stability of the intracellular environment and provide energy. It can also participate in the growth, proliferation and apoptosis of tumor cells through autophagy-related genes and signaling pathways. Radiotherapy is one of the main treatments for cancer, whereas tumor cells often have radiation resistance, which reduces the clinical efficacy. Previous studies have demonstrated that autophagy is associated with the radiosensitivity of tumor cells, but the conclusions are different. In this article, different effects of autophagy upon the radiosensitity of tumor cells were reviewed. Key words: Autophagy; Neoplasm/radiotherapy

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来源期刊

中华放射肿瘤学杂志

自引率

0.00%

发文量

6375

期刊介绍： The Chinese Journal of Radiation Oncology is a national academic journal sponsored by the Chinese Medical Association. It was founded in 1992 and the title was written by Chen Minzhang, the former Minister of Health. Its predecessor was the Chinese Journal of Radiation Oncology, which was founded in 1987. The journal is an authoritative journal in the field of radiation oncology in my country. It focuses on clinical tumor radiotherapy, tumor radiation physics, tumor radiation biology, and thermal therapy. Its main readers are middle and senior clinical doctors and scientific researchers. It is now a monthly journal with a large 16-page format and 80 pages of text. For many years, it has adhered to the principle of combining theory with practice and combining improvement with popularization. It now has columns such as monographs, head and neck tumors (monographs), chest tumors (monographs), abdominal tumors (monographs), physics, technology, biology (monographs), reviews, and investigations and research.