隐藏的生物化学化石揭示了益生元时代糖酵解的进化轨迹

IF 3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
M. Kalapos, L. de Bari
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引用次数: 0

摘要

糖酵解存在于几乎所有现存的生物体中。本文在生命起源的化学自养理论框架下提出了糖酵解的进化轨迹。在该方案中,三糖和三糖-磷酸被指定为起始点。六碳中间体和三碳中间体分别向糖异生和糖酵解方向发展,不同于酶促糖酵解自下而上的发展。酶促反应机制的研究表明,这些酶包含了非酶促阶段的化学机制,从而有可能确定乙二醛酶和甘油醛3 -磷酸脱氢酶以及甲基乙二醛合酶和三糖磷酸异构酶之间的亲缘关系。这一发展轨迹可能会揭示糖酵解在非酶时代是如何发展的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hidden biochemical fossils reveal an evolutionary trajectory for glycolysis in the prebiotic era
Glycolysis is present in nearly all organisms alive today. This article proposes an evolutionary trajectory for the development of glycolysis in the framework of the chemoautotrophic theory for the origin of life. In the proposal, trioses and triose‐phosphates were appointed to starting points. The six‐carbon and the three‐carbon intermediates developed in the direction of gluconeogenesis and glycolysis, respectively, differing from the from‐bottom‐to‐up development of enzymatic glycolysis. The examination of enzymatic reaction mechanisms revealed that the enzymes incorporated chemical mechanisms of the nonenzymatic stage, making possible to identify kinship between glyoxalases and glyceraldehyde 3‐phosphate dehydrogenase as well as methylglyoxal synthase and triose‐phosphate isomerase. This developmental trajectory may shed light on how glycolysis might have developed in the nonenzymatic era.
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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
6.60
自引率
2.90%
发文量
303
审稿时长
1 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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