产前多药使用和出生体重状况对儿童生长的纵向影响

IF 0.7 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Childrens Health Care Pub Date : 2022-06-02 DOI:10.1080/02739615.2022.2078826

S. Weerakoon, Baojiang Chen, M. Harrell, D. Vidot, S. Messiah

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引用次数: 0

摘要

摘要：母亲用药会导致低出生体重，但对长期儿童生长的了解较少。该分析的目的是纵向测量子宫内接触药物的儿童的人体测量生长情况。我们使用了国家药物滥用研究所（NIDA）资助的母亲生活方式研究（MLS）的数据。混合效应分段回归纵向评估了2-16年的BMI百分位数。出生前接触过多烟草/阿片类药物的低出生体重儿的儿童BMI百分位数低于2-16岁未接触过的儿童。对于那些出生体重较低的人来说，特定的药物组合似乎会在不同的时间点延迟或加速整个儿童期的生长。

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Longitudinal effect of prenatal polydrug use and birthweight status on pediatric growth

ABSTRACT Maternal drug use causes low birthweight but less is known about longer-term pediatric growth. The purpose of this analysis was to longitudinally measure anthropometric growth among children exposed to drugs in utero. We used data from the National Institute on Drug Abuse (NIDA)-funded Maternal Lifestyle Study (MLS). Mixed effects piecewise regression longitudinally assessed BMI percentile from 2–16 years. Those born low birthweight prenatally exposed to poly tobacco/opioid use had lower pediatric BMI percentiles than those unexposed from 2–16 years. Specific combinations of drug use appear to delay or accelerate growth across childhood at different points for those born low birthweight.

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来源期刊

Childrens Health Care PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

1.90

自引率

11.10%

发文量