基于既往治疗患者数据库的癌症IMRT自动规划的可行性

中华放射肿瘤学杂志 Pub Date : 2020-02-15 DOI:10.3760/CMA.J.ISSN.1004-4221.2020.02.014

Jihong Chen, P. Bai, Wenjuan Chen, Kaiqiang Chen, Qi-xin Li, Xiu-chun Zhang, Yitao Dai, X. Weng, Jiewei Qian

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引用次数: 0

摘要

目的基于重叠体积直方图（OVH）数据库和高质量宫颈IMRT计划，开发并评价癌症自动调强放射治疗（IMRT）方案。方法建立一个由200例癌症患者的高质量IMRT计划和OVH组成的数据库。将另外26例癌症患者的OVH转换为灰度图像，以计算图像与数据库中的图像的相似性。从具有最高图像相似性的数据库中选择患者的计划优化功能，并利用固有的Pinnacle3脚本自动生成IMRT计划。最后，对自动和手动计划的剂量测量参数、计划质量和设计时间进行了统计比较。结果两种方案的目标覆盖率、一致性指数和同质性指数差异无统计学意义（均P>0.05），自动方案的V40、V45和直肠平均剂量分别比手动方案显著降低6.1%、1.3%和50.7cGy（均P<0.05），方案设计时间缩短71%。结论基于OVH数据库和高质量IMRT计划的自动IMRT计划不仅可以显著缩短计划设计时间，而且可以在不影响目标覆盖率和一致性指数的情况下降低正常组织的照射剂量。关键词：宫颈肿瘤/调强放射治疗；重叠体积直方图；自动计划

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Feasibility of automatic IMRT planning for cervical cancer based on a database of previously-treated patients

Objective To develop and evaluate an automatic intensity-modulated radiation therapy (IMRT) program for cervical cancer based on a database of overlap volume histogram (OVH) and high-quality cervical IMRT plans for previously-treated patients. Methods A database consisting of high-quality IMRT plans and OVHs from 200 cervical cancer patients was established. OVHs of another 26 cervical cancer patients were converted into gray level images to calculate the image similarity compared with those from the database. The planning optimization function of the patients from the database with the highest image similarity was selected and inherent Pinnacle3 scripts were utilized to automatically generate IMRT plan. Finally, the dosimetric parameters, plan quality and design time were statistically compared between the automatic and manual plans. Results The target coverage, conformity index and homogeneity index did not significantly differ between two plans (all P>0.05). The V40, V45 and mean dose for the rectum in the automatic plans were significantly decreased by 6.1%, 1.3% and 50.7 cGy than those in the manual plans (all P 0.05). The plan design time was shortened by 71% in the automatic plans. Conclusions The automatic IMRT plans based on a database of OVH and high-quality IMRT plans can not only significantly shorten the plan design time, but also reduce the irradiated dose of normal tissues without compromising the target coverage and conformity index. Key words: Cervical neoplasm/intensity-modulated radiation therapy; Overlap volume histogram; Automatic plan

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来源期刊

中华放射肿瘤学杂志

自引率

0.00%

发文量

6375

期刊介绍： The Chinese Journal of Radiation Oncology is a national academic journal sponsored by the Chinese Medical Association. It was founded in 1992 and the title was written by Chen Minzhang, the former Minister of Health. Its predecessor was the Chinese Journal of Radiation Oncology, which was founded in 1987. The journal is an authoritative journal in the field of radiation oncology in my country. It focuses on clinical tumor radiotherapy, tumor radiation physics, tumor radiation biology, and thermal therapy. Its main readers are middle and senior clinical doctors and scientific researchers. It is now a monthly journal with a large 16-page format and 80 pages of text. For many years, it has adhered to the principle of combining theory with practice and combining improvement with popularization. It now has columns such as monographs, head and neck tumors (monographs), chest tumors (monographs), abdominal tumors (monographs), physics, technology, biology (monographs), reviews, and investigations and research.