微卫星不稳定性对癌症预后及疗效预测的意义

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-03-28 DOI:10.3760/CMA.J.CN115355-20190623-00265

Linghua Meng, Hai-Zhi Wu, T. Liang

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引用次数: 0

摘要

微卫星不稳定性（MSI）是由DNA错配修复（MMR）蛋白缺乏引起的，与各种肿瘤的发生、发展、预后和疗效预测密切相关。MSI-H（MSI-H）和错配修复蛋白缺乏（dMMR）可能是癌症患者预后良好的预测因素，也是可切除癌症化疗疗效的负预测因素。MSI-H/dMMR可作为预测免疫检查点抑制剂对晚期癌症有效治疗结果的标志物，但其在晚期癌症姑息化疗中的预测作用尚不清楚。本文综述了MSI/MMR与癌症预后及疗效预测的关系。关键词：胃肿瘤；微卫星不稳定性；错配修复蛋白；预后；疗效预测

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Significance of microsatellite instability for the prognosis and efficacy prediction in gastric cancer

Microsatellite instability (MSI) is caused by the deficiency of DNA mismatch repair (MMR) protein, which is closely related to the occurrence, development, prognosis and efficacy prediction of various tumors. MSI-high (MSI-H) and mismatch repair protein deficiency (dMMR) might be a predictor factor for the good prognosis of patients with gastric cancer, and a negative predictor factor for the chemotherapy efficacy of resectable gastric cancer. MSI-H/dMMR can be used as a marker for predicting the effective treatment outcome of immune checkpoint inhibitors in advanced gastric cancer, however, the predictive role in palliative chemotherapy of advanced gastric cancer is still unclear. This paper reviews the progress of the association of MSI/MMR with prognosis and efficacy prediction in gastric cancer. Key words: Stomach neoplasms; Microsatellite instability; Mismatch repair protein; Prognosis; Efficacy prediction

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.