镉和毒死蜱对Wistar大鼠脑、肝、肾脂质过氧化的影响

Q4 Pharmacology, Toxicology and Pharmaceutics

Toxicology International Pub Date : 2023-02-07 DOI:10.18311/ti/2022/v29i4/30251

Y. Ravikumar, D. Madhuri, M. Lakshman, A. Gopalareddy, B. Kalakumar, B. Anilkumar

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引用次数: 0

摘要

这项工作由4组设计，为期28天。1：控制。2:CdCl2@22.5mg kg b.wt/口服。3:CPF@25 mg/kg b.wt/每次口服。4：CdCl2@22.5mg+CPF@25 mg/kg b.wt/每次口服。在第15天和第29天，G-2、3和4中观察到较高的肝、肾和脑TBARS平均值。第2组的肝脏切片显示第3组有轻度退行性变化；第4组为轻度至中度门静脉周围纤维化。第2组肾切片显示肾小球缩小、坏死；肾切片显示肾小管上皮变性坏死，其中第3组管腔内有铸型，第4组管腔内无铸型。第2组的脑切片显示轻度血管周围凹陷，第3组和第4组的浦肯野细胞轻度至中度变性。由于组合污染物的协同作用，G-4的影响比单个组更严重。

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Cadmium and Chlorpyrifos Induced Lipid Peroxidation in Brain, Liver and Kidney of Wistar Rats

The work was designed with 4 groups for 28 days. 1: Control. 2: CdCl2 @ 22.5mg/ kg b.wt / oral. 3: CPF @ 25 mg/ kg b.wt /per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Higher mean values of liver, kidney and brain TBARS were observed in G-2, 3 and 4 on 15th and 29th day. Liver section in group 2 revealed mild degenerative changes in group 3; in group 4 mild to moderate peri portal fibrosis. Kidney section in group 2 showed shrunken glomeruli, necrosis; kidney section showed degeneration and necrosis of tubular epithelium with casts in the lumen in group 3 and necrosis with casts in the lumen in group 4. Brain section in group 2 showed mild perivascular cuffing, mild to moderate degeneration of Purkinji cells in group 3 and in group 4 degeneration of Purkinje cells. Effects in G-4 were severe than individual groups due to synergistic action of the combined pollutants than the individual effects.

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来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.