CAR-T细胞治疗肿瘤微环境的纳米免疫工程：对抗癌症的前进方向

Q2 Pharmacology, Toxicology and Pharmaceutics

OpenNano Pub Date : 2023-03-01 DOI:10.1016/j.onano.2023.100124

Muhammad Babar Khawar , Ali Afzal , Muddasir Hassan Abbasi , Nadeem Sheikh , Haibo Sun

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引用次数: 1

摘要

嵌合抗原受体(CAR) T细胞治疗是一个新兴的主题，其治疗效果后，血液转移。然而，实体肿瘤存在许多障碍，这些障碍一直是引导car在实体肿瘤微环境(TME)中取得另一个胜利的靶心。为了对抗实体肿瘤，car - t细胞的构建、转染和输送都必须采用纳米工程技术，以便在临床试验中取得更好的效果和成功。在这篇综述中，我们讨论了纳米技术的一些潜在和新颖的应用，以设计出性能更好的靶向固体TME的car。此外，我们强调了纳米免疫工程未来发展的潜在差距和克服策略。

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Nano-immunoengineering of CAR-T cell therapy against tumor microenvironment: The way forward in combating cancer

Chimeric antigen receptor (CAR) T cell treatment is an emerging subject following its curative response in hematological metastasis. However, solid tumors present a number of obstructions which have been a bull's eye to steer the CARs toward another victory in solid tumor microenvironment (TME). To combat against solid tumors, the construction, transfection and delivery of CARs is obliged to nano-engineering for better results and success in clinical trials. Herein, in this minireview, we discuss some of the potential and novel applications of nanotechnology to engineer better performing CARs to target solid TME. Moreover, we highlight potential gaps and strategies to overcome for future advancements in nano immunoengineering.

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来源期刊

OpenNano Medicine-Pharmacology (medical)

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

50 days

期刊介绍： OpenNano is an internationally peer-reviewed and open access journal publishing high-quality review articles and original research papers on the burgeoning area of nanopharmaceutics and nanosized delivery systems for drugs, genes, and imaging agents. The Journal publishes basic, translational and clinical research as well as methodological papers and aims to bring together chemists, biochemists, cell biologists, material scientists, pharmaceutical scientists, pharmacologists, clinicians and all others working in this exciting and challenging area.